Abstract
[Background]The association between occupational physical activity(OPA)and cardiometabolic risk factors remains controversial,potentially due to differences in the associations between OPA and various cardiometabolic indicators,as well as the lack of a clearly defined optimal OPA range for multiple-indicator synergistic benefits.
[Objective]To investigate the relationship between OPA and cardiometabolic risk factors in individuals at high risk of cardiovascular disease(CVD)in Hubei Province,and to explore an optimal OPA range for multi-indicator improvements.
[Methods]Data were derived from the Hubei Province dataset of the China Health Evaluation And Risk Reduction Through Nationwide Teamwork from 2015 to 2023,including 19028 high-risk CVD individuals.OPA(metabolic equivalent·h·d-1,MET·h·d-1)was assessed using the China Kadoorie Biobank physical activity questionnaire,anthropometric measurements(height,weight,waist circumference)and cardiometabolic indicators(blood pressure,fasting blood glucose,lipid profiles)were measured.Multivariate logistic regression was used to analyze the association between logOPA quartiles(Q1-Q4)and abnormal cardiometabolic indicators,while restricted cubic spline(RCS)models were employed to explore their dose-response relationships.Subgroup and interaction analyses were also conducted by gender.
[Results]The median OPA of all participants was 12.86 MET·h·d-1(male:14.40 MET·h·d-1,female:11.14 MET·h·d-1).After adjusting for confounders,compared with the Q1 group,logOPA in the Q4 group was associated with 20%(OR=0.80,95%CI:0.72,0.89),14%(OR=0.86,95%CI:0.78,0.96),and 13%(OR=0.87,95%CI:0.79,0.95)reduction in the risk of abdominal obesity,low high-density lipoprotein cholesterol(HDL-C),and metabolic syndrome(MS),respectively,and 33%(OR=1.33,95%CI:1.18,1.49),33%(OR=1.33,95%CI:1.18,1.50),and 38%(OR=1.38,95%CI:1.21,1.57)increase in the risk of high total cholesterol(TC),high low-density lipoprotein cholesterol(LDL-C),and high non-HDL-C,respectively.Similar trends were observed in males and females,with significant positive associations of logOPA with high TC and high non-HDL-C in males(Pinteraction<0.05).The risk of low HDL-C decreased rapidly when logOPA was more than 2.213(OPA>9.14 MET·h·d-1),showing an inverted L-shaped trend.The risk of high TC,high LDL-C,and high non-HDL-C increased beyond logOPA thresholds of 3.244,2.476,and 3.377(OPA>25.64,11.89,and 29.28 MET·h·d-1),respectively,showing a J-shaped trend.However,logOPA exhibited a U-shaped nonlinear dose-response relationship with blood pressure and fasting blood glucose abnormalities(Pnon-linear<0.05),with minimal risks at logOPA 2.969 and 2.372(OPA of 19.47 and 10.72 MET·h·d-1).
[Conclusion]OPA exhibits heterogeneous dose-response patterns across cardiometabolic indicators.Integrating the inverted L-,J-,and U-shaped association patterns,we suggest an optimal OPA range of 9.14-25.64 MET·h·d-1 for multiple cardiometabolic indicators in total individuals at high-risk of CVD,with ranges of 9.61-31.34 MET·h·d-1 for males and 8.97-22.87 MET·h·d-1 for females.These findings provide critical evidence for developing OPA interventions strategies targeting high-risk population for CVD.关键词
心血管疾病/高危人群/职业体力活动/心脏代谢危险因素/适宜范围Key words
cardiovascular disease/high-risk population/occupational physical activity/cardiometabolic risk factors/optimal range分类
预防医学
