皮肤性病诊疗学杂志2025，Vol.32Issue(10)：715-721,7.DOI:10.3969/j.issn.1674-8468.2025.10.004
凉血消斑颗粒联合常规西药治疗血热风燥型银屑病的临床观察
Clinical observation on Liangxue Xiaoban Granules combined with conventional western medicine in treating psoriasis of blood-heat and wind-dryness type
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of Liangxue Xiaoban Gran-ules combined with conventional western medicine in treating psoriasis of blood-heat and wind-dry-ness type,and to explore its effects on inflammatory cytokines.Methods Ninety psoriatic pa-tients were randomly assigned to a control group(n=45)and an observation group(n=45).The control group received the standardized conventional western medicine,while the observation group was given Liangxue Xiaoban Granules in addition to the conventional treatment.After 12 weeks of treatment,outcomes were compared between the two groups,including the overall re-sponse rate,psoriasis area and severity index(PASI)score,traditional Chinese medicine(TCM)syndrome score,and the adverse reaction rates.Additionally,serum levels of interleukin-2(IL-2),interleukin-6(IL-6),interleukin-8(IL-8),and interferon-gamma(IFN-γ)were compared.Results After 12 weeks of treatment,the total effective rate was significantly higher in the obser-vation group than in the control group(97.62％vs.83.72％,P＜0.05).Compared to the con-trol group,the observation group demonstrated greater reductions in PASI score,TCM syndrome scores(generalized erythema,pruritus,dryness and scaling),and serum levels of IL-2,IL-6,IL-8,and IFN-γ(all P＜0.05 vs.the controls).No severe adverse reactions were observed in any patients during the treatment period.Conclusions The combination therapy of Liangxue Xi-aoban Granules and conventional Western medicine is safe and effective.It can significantly allevi-ate skin lesions,reduce inflammatory irritation,and improve TCM syndrome in psoriatic patients of blood-heat and wind-dryness type.关键词
银屑病/凉血消斑颗粒/中医症候积分/炎症刺激Key words
psoriasis/Liangxue Xiaoban Granules/TCM syndrome/inflammatory irrita-tion引用本文复制引用
李瑞婷,赵梦,刘燕,李静,张军鹏..凉血消斑颗粒联合常规西药治疗血热风燥型银屑病的临床观察[J].皮肤性病诊疗学杂志,2025,32(10):715-721,7.基金项目
河南省中医药科学研究专项课题(2023ZY2076) （2023ZY2076）
