皮肤性病诊疗学杂志2025，Vol.32Issue(10)：759-764,6.DOI:10.3969/j.issn.1674-8468.2025.10.011
组织驻留T细胞在炎症性皮肤病中的研究进展
Research progress on tissue-resident T cells in inflammatory skin diseases
摘要
Abstract
Tissue-resident memory T cells(TRM)play a pivotal role in skin immunity,ser-ving not only as key mediators of local immune defense but also as contributors to the onset,per-sistence,and recurrence of chronic inflammatory skin diseases.Recent studies have identified TRM as major drivers of disease relapse and chronic maintenance.This review summarizes the mechanisms underlying differentiation,residency,and survival of TRM in the skin,with an em-phasis on their subset heterogeneity and tissue-specific regulation.We further highlight recent evi-dence of TRM pathogenicity in representative diseases such as psoriasis,vitiligo,and atopic der-matitis,paying particular attention to their unique role in disease recurrence.In addition,we dis-cuss how current therapeutic interventions may influence TRM development and survival.A deeper understanding of the dual roles of TRM will provide new insights and potential breakthroughs for the precise management of chronic inflammatory skin diseases.关键词
组织驻留T细胞/炎症性皮肤病/银屑病/白癜风/特应性皮炎/固定型药疹Key words
tissue-resident T cell/inflammatory skin disorders/psoriasis/vitiligo/atopic dermatitis/fixed drug eruption引用本文复制引用
唐欣,张冲,叶茜,闫言,王宝玺..组织驻留T细胞在炎症性皮肤病中的研究进展[J].皮肤性病诊疗学杂志,2025,32(10):759-764,6.基金项目
首都卫生发展科研专项项目(CFH-2022-2-4043) （CFH-2022-2-4043）
中国医学科学院整形外科医院专项科研基金(YSZ2024CG011) （YSZ2024CG011）
