岭南现代临床外科2025，Vol.25Issue(5)：281-287,7.DOI:10.3969/j.issn.1009-976X.2025.05.001
家族聚集性胃癌的临床病理特征:一项单中心回顾性研究
Clinicopathological features of gastric cancer with familial aggregation:a single-center retrospec-tive study
李森茂 1和玄 2王鹏亮 1吴现瑞 1廖艺3
作者信息
- 1. 中山大学孙逸仙纪念医院胃肠外科,广州 510120
- 2. 广州开强纪念医院胃肠外科,广州 510235
- 3. 中山大学附属第六医院胃肠外科,广州 510655
- 折叠
摘要
Abstract
Objective To investigate the clinicopathological characteristics of familial clustering gastric cancer and compare the differences among probands with different types of family history,providing clues for exploring the unique genetic background of familial gastric cancer in Chinese,particularly East Asian populations.Methods Data from 282 gastric cancer patients who underwent surgery at the Sixth Affiliated Hospital of Sun Yat-sen University between January 1 and December 31,2018,were retrospectively collected.Valid family history of malignant tumors was obtained via telephone follow-up,with 184 patients ultimately included in the analysis.Probands were divided into five cohorts based on family history:overall positive/negative family history,positive/negative family history of gastric cancer,positive/negative family history of colorectal cancer,HDGC/non-HDGC(according to 2015 IGCLC criteria),and FIGC/non-FIGC(according to 1999 IGCLC criteria).The epidemiological and clinico-pathological characteristics of probands across cohorts were compared.Results Among the 184 probands,58(31.5%)had a positive family history of malignant tumors.Gastric cancer was the most commonly clustered malignancy within these families(15/58,25.9%).Cohort analysis revealed that probands in the overall positive family history group(P=0.026),the positive gastric cancer family history group(P=0.011),and families meeting the FIGC criteria(P=0.004)had a significantly higher rate of HER2 positivity on immunohistochemistry compared to their respective negative or non-FIGC groups.Additionally,the positive gastric cancer family history group had a higher number of tumor deposits(P=0.042).Probands from HDGC families exhibited characteristics including younger age and a higher proportion of poorly differentiated and diffuse-type gastric cancers.Conclusion Significant familial clustering of gastric cancer exists in the patient population from Southern China.Probands with a family history of gastric cancer,particularly those meeting FIGC criteria,exhibit a distinct feature of HER2 protein overexpression.This suggests that the underlying genetic mechanism may differ from the CDH1 mutation-associated HDGC common in Western populations or Lynch syndrome.The HER2-related signaling pathway may play an important role in the pathogenesis of familial clustering gastric cancer in the Chinese population.关键词
胃癌/家族聚集性/临床病理特征/HER2/家族性肠型胃癌(FIGC)/回顾性研究Key words
gastric cancer/familial clustering/clinicopathological characteristics/HER2/familial intestinal gastric cancer/retrospective study分类
临床医学引用本文复制引用
李森茂,和玄,王鹏亮,吴现瑞,廖艺..家族聚集性胃癌的临床病理特征:一项单中心回顾性研究[J].岭南现代临床外科,2025,25(5):281-287,7.
