岭南现代临床外科2025，Vol.25Issue(5)：288-296,9.DOI:10.3969/j.issn.1009-976X.2025.05.002
探究ETV4与结直肠癌的关系
Exploring the relationship between ETV4 and colorectal cancer
刘锦裕 1国强 2马兴越 1陈会文 1徐鸿超1
作者信息
- 1. 内蒙古科技大学包头医学院,内蒙古 包头 014010
- 2. 内蒙古科技大学包头医学院第一附属医院,内蒙古 包头 014010
- 折叠
摘要
Abstract
Objective To explore the relationship between ETS transcription factor 4(ETV4)and colorectal cancer.Methods Colorectalcancer tissues and adjacent tissues from 40 cancer patients were collected.RT-qPCR and immunohistochemistry were used to detect ETV4 expression levels.Bioinformatics methods were applied:cBioPortal for ETV4 mutation analysis,String to extract its protein-protein inter-action network,UALCAN to analyze the correlation between ETV4 expression and clinical data like cancer stage,lymph node metastasis,age,and gender,and Kaplan-Meier Plotter to analyze the relation-ship between ETV4 expression and patient prognosis.Results RT-qPCR and immunohistochemistry showed that ETV4 expression was significantly higher in cancer tissues than in adjacent tissues(P<0.01).cBioPortal showed that ETV4 mutations in colorectal cancer mainly included missense and splice muta-tions.UALCAN analysis indicated that ETV4 expression was correlated with TNM stage,histological subtype,and TP53 mutation status(P<0.05),but not with age,gender,race,or weight(P>0.05).Kaplan-Meier analysis demonstrated that high ETV4 expression was associated with significantly improved overall survival(OS;Logrank P=0.031,HR=0.8,95%CI:0.66～0.98)and post-progression survival(PPS;Logrank P=0.05,HR=0.64,95%CI:0.47～0.88)in colorectal cancer patients.Conclusion The upregulation of ETV4 in colorectal cancer tissues correlates with a better prognosis,indicating its potential as a promising prognostic biomarker and a novel therapeutic target.关键词
结直肠癌/ETV4/生物信息学Key words
colorectal cancer/ETV4/bioinformatics分类
临床医学引用本文复制引用
刘锦裕,国强,马兴越,陈会文,徐鸿超..探究ETV4与结直肠癌的关系[J].岭南现代临床外科,2025,25(5):288-296,9.
