岭南现代临床外科2025，Vol.25Issue(5)：297-301,5.DOI:10.3969/j.issn.1009-976X.2025.05.003
肝癌术后MVI阳性的多因素分析
Multivariate analysis of MVI-positivity in hepatocellular carcinoma
摘要
Abstract
Objective To investigate the influencing factors of postoperative microvascular invasion(MVI)in hepatocellular carcinoma(HCC)patients and provide a theoretical basis for neoadjuvant therapy.Methods Clinical data of 995 HCC patients who underwent surgery at Sun Yat-sen Memorial Hospital between January 2020 and December 2023 were retrospectively analyzed.Univariate and multi-variate logistic regression analyses were performed to identify independent risk factors for MVI positivity.Results A total of 995 patients were included,with an MVI positivity rate of 38.4%(382/995).Univariate analysis revealed significant differences between MVI-positive and MVI-negative groups in tumor stage(P<0.001),differentiation grade(P<0.001),and proportion of preoperative adjuvant therapy(P=0.044).Multivariate analysis demonstrated that advanced tumor stage(OR=3.171)and absence of preoperative adjuvant therapy(OR=3.312)were independent risk factors for MVI positivity,while well-differentiated tumors served as a protective factor(OR=0.275)(all P<0.05).Conclusion Higher tumor stage,poorer differentiation,and absence of preoperative adjuvant therapy significantly increase the risk of postopera-tive MVI in HCC patients.Individualized preoperative adjuvant therapy based on tumor stage and differ-entiation grade may reduce MVI risk.关键词
肝细胞肝癌/微血管侵犯(MVI)/新辅助治疗/多因素分析Key words
hepatocellular carcinoma/microvascular invasion/neoadjuvant therapy/multivariate analysis分类
临床医学引用本文复制引用
胡啸,彭林辉..肝癌术后MVI阳性的多因素分析[J].岭南现代临床外科,2025,25(5):297-301,5.基金项目
国家卫生健康委人才交流服务中心(RCLX2315049) （RCLX2315049）
