老年医学与保健2025，Vol.31Issue(5)：1302-1307,6.
艾多沙班在超高龄心房颤动患者中的有效性及安全性分析
Analysis of efficacy and safety of edoxaban in very elderly patients with atrial fibrillation
韦伟 1贾宁 1赵雪静 1左瑞平 1张艳苓 2高鹏丽 2佟海锋 1刘畅1
作者信息
- 1. 中国人民解放军总医院京东医疗区综合内科(全科医学科),北京 101149
- 2. 中国人民解放军总医院第七医学中心心血管内科,北京 100010
- 折叠
摘要
Abstract
Objective To analyze the efficacy and safety of edoxaban in very elderly patients with atrial fibrillation(AF)and the influence factors of bleeding events.Methods A retrospective analysis was conducted on 448 AF patients aged≥85 years treated between July 2023 and January 2025,including 212 cases in the edoxaban group and 236 cases in the rivaroxaban group.The clinical data of the two groups were collected.After a 6-month follow-up,the efficacy endpoints,safety endpoints and other adverse reactions of the patients during the medication period were recorded.Multivariate Logistic regression was used to identify factors influencing bleeding events in the edoxaban group.Results There was no statistically significant difference in the incidence of efficacy endpoint events between the two groups(2.36％vs 2.53％,P＞0.05).The proportion of patients experiencing bleeding events in the edoxaban group was significantly lower than that in the rivaroxaban group(5.19％vs 10.59％,P＜0.05).Compared with the non-bleeding group,patients in the bleeding group had significantly lower body weight,lower body mass index(BMI),and higher HAS-BLED scores,all with statistically significant differences(P＜0.05).Multivariate Logistic regression analysis showed that high HAS-BLED score and concomitant antiplatelet drug use were independent risk factors for bleeding in the edoxaban group,while a higher BMI was a protective factor.Conclusion The efficacy of edoxaban in very elderly AF patients shows no significant difference from that of rivaroxaban,and edoxaban has better safety.Concomitant antiplatelet therapy,higher HAS-BLED scores,and lower BMI may increase the risk of bleeding in very elderly AF patients treated with edoxaban.关键词
心房颤动/超高龄/艾多沙班/利伐沙班/出血Key words
atrial fibrillation/very elderly/edoxaban/rivaroxaban/bleeding引用本文复制引用
韦伟,贾宁,赵雪静,左瑞平,张艳苓,高鹏丽,佟海锋,刘畅..艾多沙班在超高龄心房颤动患者中的有效性及安全性分析[J].老年医学与保健,2025,31(5):1302-1307,6.
