国际眼科杂志2025，Vol.25Issue(11)：1735-1739,5.DOI:10.3980/j.issn.1672-5123.2025.11.04
电针太阳穴对形觉剥夺性近视小鼠眼参数和睫状体β-catenin与integrin β1表达的影响
Effect of electroacupuncture at the Taiyang acupoint on refractive parameters and the expression of β-catenin and integrin β1 in ciliary body in mice with form-deprivation myopia
摘要
Abstract
AIM:To investigate the effects of electroacupuncture at the Taiyang on refractive parameters and the expression of β-catenin and integrin β1 in the ciliary body of mice with form-deprivation myopia(FDM). METHODS:A total of 48 3-week-old healthy C57BL/6J mice were randomly divided into 4 groups:normal control(NC),FDM group,sham acupuncture(sham),and electroacupuncture at Taiyang acupoint(Taiyang),with 12 mice in each group.Mice in the FDM,sham,and Taiyang groups,wore translucent custom-made eye masks on the right eye to induce myopia.The Taiyang group received electroacupuncture stimulation at the Taiyang acupoint,while the sham group underwent non-penetrating stimulation with a blunt wooden stick.No intervention was performed on the NC group.Refraction and axial length were measured by infrared autorefractor and optical coherence tomography(OCT)before modeling and at 4 wk after modeling.The expression levels of β-catenin and integrin β1 in the ciliary body of mice at 4 wk after modeling were detected using quantitative real-time PCR(qPCR)and Western blotting(WB). RESULTS:After modeling for 4 wk,compared with the NC group,the FDM and sham groups showed significantly decreased refractive power(both P＜0.05),elongated axial length(both P＜0.05),and increasedβ-catenin and integrin β1 expression.Compared with the FDM and sham groups,the Taiyang group showed significantly increased refractive power(both P＜0.05),shortened axial length(both P＜0.05),and decreasedβ-catenin and integrin β1 expression. CONCLUSION:Electroacupuncture stimulation at the Taiyang acupoint effectively delayed the progression of myopia in FDM mice,and this effect may be partially mediated through modulating the expression of β-catenin and integrin β1 in the ciliary body.关键词
形觉剥夺性近视/电针/睫状体/连环蛋白β1(β-catenin)/整合素β1(integrin β1)Key words
form-deprivation myopia/electroacupuncture/ciliary body/β-catenin/integrin β1引用本文复制引用
陈禄,滕悦,蒋文君,毕宏生..电针太阳穴对形觉剥夺性近视小鼠眼参数和睫状体β-catenin与integrin β1表达的影响[J].国际眼科杂志,2025,25(11):1735-1739,5.基金项目
山东省自然科学基金项目(No.ZR2021LZY045) Natural Science Foundation of Shandong Province(No.ZR2021LZY045) （No.ZR2021LZY045）
