国际眼科杂志2025，Vol.25Issue(11)：1764-1770,7.DOI:10.3980/j.issn.1672-5123.2025.11.08
基因在原发性开角型青光眼中的研究进展
Research progress of genes in primary open angle glaucoma
摘要
Abstract
Primary open angle glaucoma(POAG)is the most common type of glaucoma,with common causes including variations in trabecular tissue and increased venous pressure.POAG has a certain genetic tendency,and POAG with an autosomal dominant inheritance pattern is mainly caused by single gene mutations.Studies have found that the pathogenesis of POAG may be related to key pathogenic genes(MYOC,OPTN,WDR 36),as well as mitochondrial dysfunction,oxidative stress,and epigenetic regulation.At present,the clinical treatment options for POAG mainly include enhancing trabecular meshwork function,inhibiting aqueous humor production,neuroprotection and regeneration of retinal ganglion cells,and applying gene editing technology,all of which have achieved certain results.However,there is no unified research on the relationship between the occurrence of POAG and genes,as well as treatment plans.The article explores new targets and treatment strategies for POAG gene therapy by analyzing the role of genes in the pathogenesis of POAG,aiming to provide reference for clinical treatment of this disease.关键词
原发性开角型青光眼/线粒体功能障碍/表观遗传调控/视网膜神经节细胞神经保护与再生/基因编辑技术Key words
primary open angle glaucoma/mitochondrial dysfunction/epigenetic regulation/neuroprotection and regeneration of retinal ganglion cells/gene editing technology引用本文复制引用
胡昊,贾大东,王旖瑶,梁亮..基因在原发性开角型青光眼中的研究进展[J].国际眼科杂志,2025,25(11):1764-1770,7.基金项目
国家自然科学基金项目(No.81770920) National Natural Science Foundation of China(No.81770920) （No.81770920）
