国际眼科杂志2025，Vol.25Issue(11)：1771-1776,6.DOI:10.3980/j.issn.1672-5123.2025.11.09
肠道菌群在干眼中的肠-眼轴免疫代谢调控机制及治疗新策略
Immune-metabolic regulatory mechanism of the gut-eye axis of intestinal flora in dry eye and new treatment strategies
摘要
Abstract
Dry eye disease is a multifactorial chronic ocular surface disorder that is challenging to manage because its pathogenesis is not well understood.The gut-eye axis theory provides insights into its pathogenesis to guide prevention and treatment.Intestinal flora dysbiosis induces dry eye disease through complex mechanisms involving inflammation,ocular surface microbiota,nerve damage,and microbial metabolites.This article reviews the immunometabolic regulation of the gut-eye axis and summarizes gut flora-targeted interventions(fecal microbiota transplantation,probiotic supplementation,and dietary modification)to provide a theoretical basis for dry eye disease prevention and treatment.关键词
干眼/肠-眼轴/肠道菌群/眼表微生物群/代谢产物Key words
dry eye/gut-eye axis/gut microbiome/ocular surface microbes/metabolite引用本文复制引用
刘晓彤,孙心怡,高卫萍..肠道菌群在干眼中的肠-眼轴免疫代谢调控机制及治疗新策略[J].国际眼科杂志,2025,25(11):1771-1776,6.基金项目
国家自然科学基金资助项目(No.82474638) （No.82474638）
江苏省干部保健科研课题项目(No.BJ23012) National Natural Science Foundation of China(No.82474638) （No.BJ23012）
Research Project on the Health Care of Cadres in Jiangsu Province(No.BJ23012) （No.BJ23012）
