国际眼科杂志2025，Vol.25Issue(11)：1777-1784,8.DOI:10.3980/j.issn.1672-5123.2025.11.10
脂质体在眼科药物递送中的创新设计与研究进展
Innovative design and research progress of liposomes in ocular drug delivery
摘要
Abstract
The complex anatomical structure and physiological barriers of the eye present substantial challenges for local drug delivery,leading to suboptimal ocular drug bioavailability,which typically remains below 5％in conventional ophthalmic formulations.Frequent or high-dose administration not only increases the treatment burden but also heightens the risk of both local and systemic adverse effects.Liposomes,as an advanced drug delivery system,enhance ocular bioavailability through their biocompatibility and targeted delivery properties.Recent innovations in surface modification and functionalization have further enhanced their ability to overcome ocular barriers and facilitate controlled drug release.Liposome-based formulations have demonstrated significant therapeutic potential for diseases such as glaucoma and dry eye syndrome.Drawing on the research advancements over the past 5 a,this article systematically reviews the innovative design strategies and applications of liposomes in ocular drug delivery,with the aim of providing theoretical basis and technical reference for the development of new ophthalmic drugs.关键词
脂质体/药物递送/眼科疾病Key words
liposomes/drug delivery/ophthalmic diseases引用本文复制引用
董晓云,宋继科,毕宏生..脂质体在眼科药物递送中的创新设计与研究进展[J].国际眼科杂志,2025,25(11):1777-1784,8.基金项目
国家重点研发计划(No.2019YFC1710203) （No.2019YFC1710203）
山东省自然科学基金项目(No.ZR2021LZY045) National Key Research and Development Program of China(No.2019YFC1710203) （No.ZR2021LZY045）
Natural Science Foundation of Shandong Province(No.ZR2021LZY045) （No.ZR2021LZY045）
