摘要
Abstract
AIM:To observe the efficacy of intravitreal Conbercept injection(IVC)in diabetic neovascular glaucoma(NVG).
METHODS:Retrospective study.Totally 57 patients(57 eyes)with NVG(stage Ⅱ)secondary to proliferative diabetic retinopathy(PDR)treated in our hospital were collceted from January 2019 to December 2022.Among them,30 patients(30 eyes)were treated by IVC and panretinal photocoagulation(PRP)in the observation group,and 27 patients(27 eyes)were treated by PRP in the control group.The best corrected visual acuity(BCVA,LogMAR),intraocular pressure,neovascularization of the iridocorneal angle(NVA),central macular thinkness(CMT)changes and disease progression were analyzed with a follow-up of 2 years.
RESULTS:There were no significant differences in baseline characteristics between the two groups(P＞0.05).At the last follow-up,the BCVA in the observation group was better than the control group(P＜0.05).The intraocular pressure,CMT and progression of NVA in the observation group were less than the control group(all P＜0.05).The patients with NVG developed from stage Ⅱ to stage Ⅲ in the observation group was less than the control group(P＜0.05).In the observation group,the BCVA improved compared with preoperative at 6 mo(P＜0.05).In the control group,the BCVA decreased compared with preoperative after 24 mo(P＜0.05).Multiple linear regression analysis indicated that NVG progression and intraocular pressure were factors affecting BCVA(LogMAR)changes(β=0.511,0.014;t=4.461,2.092;P＜0.01,0.041,respectively).In the observation group,the IOP decreased at 1,6 and 12 mo compared with preoperative(all P＜0.05),while there were no significant differences at 18 and 24 mo compared with preoperative(all P＞0.05).In the control group,the intraocular pressure decreased at 6 mo compared with preoperative(P＜0.05),while there were no significant differences at 1,12,18 and 24 mo compared with preoperative(all P＞0.05).There were no significant difference about the types of glaucoma drugs between the observation group and the control group(all P＞0.05).There were no infectious endophthalmitis and other complications observed in both groups.
CONCLUSION:IVC combined with PRP demonstrates superior efficacy over PRP monotherapy in treating NVG(stage Ⅱ)secondary to PDR.IVC combined with PRP showed better outcomes in controlling iris neovascularization,slowing visual impairment progression,reducing intraocular pressure,and delaying disease advancement.关键词
玻璃体内注射康柏西普/全视网膜光凝/糖尿病性新生血管性青光眼Key words
intravitreal Conbercept injection/panretinal photocoagulation/diabetic neovascular glaucoma
