南京医科大学学报（自然科学版）2025，Vol.45Issue(11)：1580-1585,6.DOI:10.7655/NYDXBNSN250886
单中心胰腺腺泡细胞癌23例临床诊治分析
Clinical diagnosis and treatment of pancreatic acinar cell carcinoma:a single-center analysis of 23 cases
摘要
Abstract
Objective:To investigate the clinical,imaging,and pathological characteristics,diagnosis,treatment,and prognosis of pancreatic acinar cell carcinoma(ACC).Methods:A retrospective analysis was conducted on clinical data of patients with pathologically confirmed ACC admitted to the First Affiliated Hospital of Nanjing Medical University from April 2015 to December 2024.The clinical manifestations,imaging and pathological features,diagnosis,treatment,and prognosis were summarized.Results:A total of 23 ACC cases were enrolled,with 15 males and a median age of 63 years.The most common presenting symptom was abdominal pain(13 cases).Tumors were located in the pancreatic head(15 cases),pancreatic body/tail(7 cases),and diffusely involved the entire pancreas(1 case).The mean tumor diameter was(54±34)mm.Tumors presented as solid(8 cases,44.4%),solid with necrosis(5 cases,27.8%),and cystic-solid(5 cases,27.8%).Surgical resection was performed in 22 cases.Pathologically,21 cases were pure ACC,one case was mixed with ductal adenocarcinoma,and one case was mixed with neuroendocrine tumor.Lymph node metastasis was observed in 10 cases,and neurovascular invasion was present in 20 cases.R0 resection was achieved in 19 cases.Postoperative adjuvant chemotherapy was administered to 15 cases.Among 21 patients with effective follow-up,the median overall survival was 26 months,and the median recurrence-free survival was 15 months.The 1-year and 3-year survival rates were 90.5%and 44.4%,respectively.The most common sites of initial recurrence were the liver and retroperitoneal lymph nodes,followed by bone,lung,mesenteric lymph nodes,and local recurrence.Conclusion:ACC is a rare malignant tumor characterized mainly by abdominal pain,often presenting as a solid mass with aggressive features.Surgical resection combined with adjuvant chemotherapy is the main treatment approach.Postoperative surveillance should focus on the liver and retroperitoneal lymph nodes for early detection of recurrence and metastasis.关键词
胰腺腺泡细胞癌/手术治疗/化疗/生存时间Key words
acinar cell carcinoma/surgical treatment/chemotherapy/survival time分类
临床医学引用本文复制引用
胡乐,戴存才,蒋奎荣,郭峰..单中心胰腺腺泡细胞癌23例临床诊治分析[J].南京医科大学学报（自然科学版）,2025,45(11):1580-1585,6.基金项目
江苏省科教能力提升工程(江苏省医学重点学科)(ZDXK202222) （江苏省医学重点学科）
