南京医科大学学报（自然科学版）2025，Vol.45Issue(11)：1586-1597,12.DOI:10.7655/NYDXBNSN241134
中性粒细胞胞外诱捕网在肿瘤进展中的多重作用机制研究进展
Research progress on the multifaceted mechanisms of neutrophil extracellular traps in tumor progression
摘要
Abstract
Neutrophil extracellular trap(NET),a reticular structure composed of DNA fibers,histones,and antibacterial proteins released by neutrophils,can trap and eliminate foreign pathogens and play a significant role in the initiation and development of tumors.The formation and release of NET are regulated by various factors from the tumor microenvironment,including signaling molecules released by tumor cells,inflammatory cytokines,oxidative stress,and angiogenesis.In addition,NET interacts with immune cells in the tumor microenvironment,collectively shaping the immune characteristics of the tumor microenvironment and participating in critical biological processes,such as metabolic regulation of tumor cells,tumor metastasis,tumor-related thrombosis,and tumor angiogenesis,all of which impact tumor progression and patient prognosis.This review focuses on the multiple mechanisms of NET in tumor progression,explores the mechanisms of NET in regulating tumor cell proliferation and metastasis,altering tumor microenvironment,and affecting tumor angiogenesis and immune escape,as well as the potential application prospect of NET as biomarkers for clinical diagnosis and prognosis,to reveal the significant role of NET in tumor biology and provide a theoretical foundation for future research and clinical application.关键词
中性粒细胞胞外诱捕网/肿瘤微环境/肿瘤进展Key words
neutrophil extracellular traps/tumor microenvironment/tumor progression分类
临床医学引用本文复制引用
杨艳,金晨晨,张栩..中性粒细胞胞外诱捕网在肿瘤进展中的多重作用机制研究进展[J].南京医科大学学报（自然科学版）,2025,45(11):1586-1597,12.基金项目
国家自然科学基金(82274163,81803763) （82274163,81803763）
四川省自然科学基金(24NSFSC2566) （24NSFSC2566）
成都市医学科研课题(202313052876) （202313052876）
成都市第三人民医院院内科研项目(CSY-YN-01-2023-027) （CSY-YN-01-2023-027）
成都市第三人民医院PI项目(2023PI14) （2023PI14）
