南京医科大学学报（自然科学版）2025，Vol.45Issue(11)：1626-1633,1640,9.DOI:10.7655/NYDXBNSN250411
基于左心室整体纵向应变及心肌做功探讨甘油三酯-葡萄糖指数与亚临床左心室功能障碍的相关性研究
Association between triglyceride-glucose index and subclinical left ventricular dysfunction:a study based on left ventricular global longitudinal strain and myocardial work
摘要
Abstract
Objective:To investigate the independent association between the triglyceride-glucose(TyG)index and subclinical left ventricular(LV)systolic dysfunction,and to analyze its impact on left ventricular global longitudinal strain(GLS)and myocardial work indices.Methods:A total of 103 patients admitted from August 2024 to February 2025 were enrolled.Clinical parameters,biochemical indicators,and echocardiographic data were collected,and the TyG index was calculated.GLS and LV myocardial work parameters,including global work index(GWI),global constructive work(GCW),global wasted work(GWW),and global work efficiency(GWE)were obtained using GE EchoPAC software.Multivariate logistic regression analysis was employed to assess the independent association between the TyG index and impaired LV function.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive efficacy of the TyG index for LV dysfunction,calculating the area under the curve(AUC),optimal cutoff value,sensitivity,and specificity.Results:Compared to the low-TyG group,the high-TyG group exhibited significantly higher prevalence rates of hypertension(67.31%vs.43.14%),diabetes(42.31%vs.7.84%),and dyslipidemia(34.62%vs.3.92%)(all P<0.05).The absolute values of GLS(-17.60±2.65 vs.-19.82±2.12),GWI(1 672.33±308.58 vs.1 932.31±280.26 mmHg%),and GCW(1 999.46±324.11 vs.2 299.20±323.32 mmHg%)were significantly lower in the high TyG group(all P<0.001).After adjusting for age,sex,body mass index(BMI),blood pressure,dyslipidemia,and other confounders,an elevated TyG index remained an independent risk factor for reduced GLS(OR=2.982,95%CI:1.182-7.522,P=0.021),reduced GWI(OR=3.168,95%CI:1.302-7.706,P=0.011),and diminished GCW(OR=2.836,95%CI:1.250-7.309,P=0.021).ROC curve analysis demonstrated the predictive efficacy of the TyG index for reduced GLS,GWI,and GCW,with AUC values of 0.725,0.697,and 0.683,respectively.Conclusion:An elevated TyG index is independently associated with reduced GLS and myocardial work capacity,serving as a potential biomarker for subclinical LV dysfunction and highlighting its clinical utility in early risk assessment for metabolic cardiovascular diseases.关键词
甘油三酯-葡萄糖指数/左心室整体纵向应变/左室做功指数/亚临床左心功能障碍/代谢紊乱Key words
triglyceride-glucose index/left ventricular global longitudinal strain/myocardial work indices/subclinical left ventricu-lar dysfunction/metabolic disorders分类
临床医学引用本文复制引用
陈超,陶炜伟,陆美娟,何安霞,刘加宝..基于左心室整体纵向应变及心肌做功探讨甘油三酯-葡萄糖指数与亚临床左心室功能障碍的相关性研究[J].南京医科大学学报（自然科学版）,2025,45(11):1626-1633,1640,9.基金项目
国家自然科学基金(81901416) （81901416）
江苏省中医院创新发展基金专项(y2023cx30) （y2023cx30）
