南京医科大学学报（自然科学版）2025，Vol.45Issue(11)：1670-1677,8.DOI:10.7655/NYDXBNSN250300
中医药调控神经血管单元及其标志物改善阿尔茨海默病的研究进展
Research progress in improving Alzheimer's disease by regulating neurovascular units and their markers with traditional Chinese medicine
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive impairment,and its pathogenesis is very complex.In recent years,vascular abnormalities such as decreased cerebral blood flow and blood-brain barrier disruption have been found in the early stage of AD,suggesting that vascular factors play an important role in its pathogenesis.As a key structure of brain functional homeostasis,the dysfunction of the neurovascular unit(NVU),including neurons,endothelial cells,pericytes,astrocytes,microglia,and basement membrane,has been considered to be one of the common pathological bases of AD and vascular dementia.Its disorder can lead to cognitive impairment.Traditional Chinese medicine can intervene NVU function through multiple targets and pathways,improve the permeability of blood-brain barrier,reduce neuroinflammation and oxidative stress,and is expected to become an important means to treat AD.This article elaborates the research progress of NVU and its markers regulated by traditional Chinese medicine in the early diagnosis and treatment of AD.关键词
阿尔茨海默病/神经血管单元/生物标志物/中医药/综述Key words
Alzheimer's disease/neurovascular unit/biomarkers/traditional Chinese medicine/review分类
临床医学引用本文复制引用
张铭,冯晓东,潘蕊..中医药调控神经血管单元及其标志物改善阿尔茨海默病的研究进展[J].南京医科大学学报（自然科学版）,2025,45(11):1670-1677,8.基金项目
河南省中医药科学研究专项(20-21ZY1017) （20-21ZY1017）
河南省中医药传承与创新人才工程(仲景工程)-拔尖人才(CZ0325-14) （仲景工程）
河南省中医学"双一流"创建科学研究专项(HSRP-DFCTCM-2023-3-11) （HSRP-DFCTCM-2023-3-11）
