排灌机械工程学报2025，Vol.43Issue(10)：1023-1030,8.DOI:10.3969/j.issn.1674-8530.23.0276
基于差异化边界的狭窄冠脉血流动力学
Hemodynamics of narrow coronary arteries based on differentiated boundaries
摘要
Abstract
By establishing differentiated boundary conditions,the hemodynamic changes and the impact on the bifurcation site when single-branch or double-branch lesions occur in the first branch of the left coronary artery were studied.When a high degree of multibranch stenosis occured in the coro-nary artery,the use of traditional ideal boundary conditions in CFD simulation led to errors in the local hemodynamic information of the vessel.Therefore,a centralized parametric model was used to obtain the left main stem flow as a discretized boundary condition for local finite element analysis to explore the hemodynamic behavior of the asymmetric stenosis model of the first branch of the left coronary.The results show that in single-branch lesions,the stenosis region shows a reverse pressure difference,and the degree of disorder in the downstream region increases with the increase of stenosis.In double-branch lesions,the LM-LCX lesion leads to a long-term low shear stress environment in the lateral branch of the gyratory branch,and the risk of plaques is increased.Combining single and double-branch lesions,main branch lesions have a more significant effect on the bifurcation site compared with side branch lesions.The hemodynamic analysis of left coronary single and double branch lesions based on differential boundary conditions helps to gain insight into the mechanism and risk of plaque develop-ment,and provides a basis for catheter pump-assisted percutaneous coronary intervention.关键词
冠状动脉狭窄/边界条件/集中参数模型/计算流体动力学Key words
stenosis of the coronary artery/boundary condition/lumped parameter model/computational fluid dynamics分类
医药卫生引用本文复制引用
王芳群,朱凤莲,周钰,刘艳蕊,何辰杨,徐凡..基于差异化边界的狭窄冠脉血流动力学[J].排灌机械工程学报,2025,43(10):1023-1030,8.基金项目
国家自然科学基金资助项目(51677082,51805218) （51677082,51805218）
