四川精神卫生2025，Vol.38Issue(5)：392-397,6.DOI:10.11886/scjsws20250224003
免疫相关基因表达与惊恐障碍的关联研究
Research on the association between immune-related gene expression and panic disorder
摘要
Abstract
Background Genetic factor plays an important role in the pathogenesis of panic disorder.Previous studies have revealed that immune system dysregulation is closely related to mental disorders such as panic disorder,while the relationship between panic disorder and immune-related gene expression remains unclear.Objective To explore the relationship between the expression of CXCL8,IL6R,JUN,PTGS2,TGFBR1,TLR2,CCR4 genes and panic disorder,providing references for the diagnosis and treatment of panic disorder.Methods A total of 52 patients who met the diagnostic criteria for panic disorder according to the Diagnosed and Statistical Manual of Mental Disorders,fourth edition(DSM-IV)were enrolled at the Psychosomatic Medicine Center of Sichuan Provincial People's Hospital from January 2020 to March 2021.Another 72 healthy individuals matched for age and gender from Chengdu were concurrently recruited as control group.The Panic Disorder Severity Scale(PDSS)was used to assess the severity of symptoms in panic disorder patients.Quantitative real-time polymerase chain reaction(PCR)was used to detect gene expression levels in two groups.Spearman correlation analysis was adopted to determine the correlation between PDSS score and immune-related gene expression in research group.Results The expression of the JUN,PTGS2 and TGFBR1 genes were significant higher in panic disorder patients than those in control group(Z=-4.172,-2.086,-3.018,P<0.05 or 0.01).After false discovery rate(FDR)correction for multiple testing,the differential expression of JUN and TGFBR1 genes remained statistically significant between two groups(P<0.05).There was no significant difference in the expression of CCR4,CXCL8,IL6R and TLR2 genes between two groups(P>0.05).Correlation analysis revealed that the expression of the JUN gene in panic disorder patients was positively correlated with PDSS score(r=0.360,P<0.01),while the CCR4,CXCL8,IL6R,PTGS2,TGFBR1 and TLR2 genes showed no statistically significant correlation with the PDSS score(P>0.05).Conclusion The expression of the JUN and TGFBR1 genes may be associated with panic disorder,and the expression of the JUN gene correlated with the severity of panic disorder.关键词
惊恐障碍/基因表达/惊恐障碍严重程度量表/免疫Key words
Panic disorder/Gene expression/Panic disorder severity scale/Immune分类
临床医学引用本文复制引用
何雨谦,王歌曼,冉容婷,李雪莲,李雨洁,邓敏,邹志礼..免疫相关基因表达与惊恐障碍的关联研究[J].四川精神卫生,2025,38(5):392-397,6.基金项目
四川省科技厅科技计划项目(项目名称:惊恐障碍全基因组甲基化分析及抗抑郁药对差异基因甲基化及其表达的动态机制研究,项目编号:2021YJ0440)[Funded by Science and Technology Plan Project of Sichuan Provincial Department of Science and Technology(number,2021YJ0440)] （项目名称:惊恐障碍全基因组甲基化分析及抗抑郁药对差异基因甲基化及其表达的动态机制研究,项目编号:2021YJ0440）
