摘要
Abstract
Objective To analyze the risk factors for metabolic dysfunction-associated fatty liver disease(MAFLD)complicated with colorectal adenomatous polyps(CAP)and to construct a corresponding risk prediction model.Methods A total of 180 MAFLD patients were enrolled,including 102 cases with CAP(MAFLD+CAP group)and 78 cases without CAP(MAFLD group).We collected and compared the basic data of patients of the two groups,including 40 indicators of gender,age,hypertension,smoking,alcohol consumption,fecal occult blood test results,hemoglobin,platelet distribution width,fasting blood glucose,small dense low-density lipoprotein cholesterol(sdLDL-C),etc.Logis-tic Regression analysis was used to identify the influencing factors of MAFLD combined with CAP,and a predictive model was subsequently constructed.The predictive value of the model for MAFLD with CAP was evaluated using the receiver op-erating characteristic(ROC)curve.A calibration curve was plotted by using R 4.2.0 software to evaluate the consistency of the model.Internal validation of the model was performed by resampling 1,000 times using the Bootstrap method,and model accuracy was assessed using the Hosmer-Lemeshow test.Results Statistically significant differences were found in the data such as age,sex,history of hypertension,smoking history,drinking history,fecal occult blood test results,he-moglobin,platelet distribution width,fasting blood glucose,sdLDL-C,and others between the MAFLD+CAP group and MAFLD group(all P<0.05).Sex,age,fecal occult blood test results,and sdLDL-C were identified as the independent risk factors for MAFLD combined with CAP(all P<0.05).The risk prediction model based on these factors was formulat-ed as P=1/(1+e-Y),where Y=1.104×sex+1.236×fecal occult blood test+0.078×age+1.126×sdLDL-8.207,with sex(male=1,female=0)and fecal occult blood test[(weakly)positive=1,negative=0].The area under the ROC curve(AUC)of the prediction model was 0.780,with a sensitivity of 63.7%,and a specificity of 78.2%.The calibration curve of the predictive model was close to the ideal curve.Hosmer-Lemeshow test analysis showed no statistically significant difference between the predicted and actual probabilities(P=0.233),indicating good model fit.Conclusions Male sex,age,(weakly)positive fecal occult blood test,and sdLDL-C are risk factors for MAFLD complicated with CAP.The pre-diction model constructed in this study has a high predictive value.关键词
代谢相关脂肪性肝病/结直肠腺瘤性息肉/预测模型Key words
metabolic dysfunction-associated fatty liver disease/colorectal adenomatous polyps/prediction model分类
临床医学
