陕西中医2025，Vol.46Issue(11)：1487-1491,5.DOI:10.3969/j.issn.1000-7369.2025.11.008
人参养营汤合桃仁四物汤加减治疗冠心病介入术后再发心绞痛临床研究
Clinical study on modified Renshen Yangying decoction combined with Taoren Siwu decoction in treatment of recurrent angina pectoris after PCI
摘要
Abstract
Objective:To investigate clinical efficacy of modified Renshen Yangying decoction combined with Taoren Siwu decoction in treating angina pectoris recurrence after percutaneous coronary intervention(PCI)in pa-tients with coronary heart disease(CHD)of Qi-deficiency and blood-stasis syndrome type.Methods:A total of 98 CHD patients with Qi-deficiency and blood-stasis syndrome who experienced angina pectoris recurrence after PCI were randomly assigned to either control group or observation group(n=49 each)via computer-generated randomi-zation sequences sealed in envelopes.Both groups received conventional Western medical therapy.The observation group were additionally treated with modified Renshen Yangying decoction combined with Taoren Siwu decoction,clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,cardiac function indicators,angina symptom scores,myocardial injury markers,major adverse cardiovascular events(MACE)incidence,and treatment safety were evaluated post-treatment.Results:The total effective rate was significantly higher in the observation group than in the control group(P＜0.05).TCM syndrome scores were lower in the observation group(all P＜0.05).Left ventricular ejection fraction(LVEF)and cardiac output(CO)were higher,whereas left ventricular end-diastolic volume(LV-EDV)and left ventricular end-diastolic diameter(LVEDD)were lower in the observation group compared to the control group(all P＜0.05).Seattle angina questionnaire scores were higher in the observation group(all P＜0.05).Post-treatment levels of heart-type fatty acid-binding protein,myoglobin,and cardiac troponin I were lower in the ob-servation group(all P＜0.05).During the 6-month follow-up,the MACE incidence was lower in the observation group(all P＜0.05).No significant difference in adverse reaction rates was observed between the two groups(all P＞0.05).Conclusion:Modified Renshen Yangying decoction combined with Taoren Siwu decoction demonstrates fa-vorable efficacy in treating angina pectoris recurrence after PCI in CHD patients with Qi-deficiency and blood-stasis syndrome.It alleviates key TCM symptoms,improves cardiac function and angina symptoms,reduces myocardial in-jury markers,and lowers MACE incidence during follow-up,with good treatment safety.关键词
冠心病/心绞痛/气虚血瘀/经皮冠状动脉介入术/人参养营汤/桃仁四物汤Key words
Coronary heart disease/Angina pectoris/Qi deficiency and blood stasis/Percutaneous coronary in-tervention/Renshen Yangying decoction/Taoren Siwu decoction分类
临床医学引用本文复制引用
张雁,黄晓佳,曹守沛,刘学谦..人参养营汤合桃仁四物汤加减治疗冠心病介入术后再发心绞痛临床研究[J].陕西中医,2025,46(11):1487-1491,5.基金项目
国家自然科学基金资助项目(82305126) （82305126）
