神经病学与神经康复学杂志2025，Vol.21Issue(5)：344-351,8.DOI:10.12022/jnnr.2025-0064
喹硫平联合酒精中毒后出现横纹肌溶解合并周围神经损伤:1例报告及文献复习
Rhabdomyolysis with peripheral neuropathy following combined quetiapine and alcohol intoxication:A case report and literature review
摘要
Abstract
Objective:To report the clinical characteristics and rehabilitation course of a patient who developed rhabdomyolysis with peripheral nerve injury following combined quetiapine and alcohol intoxication,and to review the literature to enhance understanding of quetiapine intoxication and emphasize the importance of early rehabilitation intervention in patients with concomitant peripheral nerve injury to improve prognosis. Methods:The clinical characteristics,electromyography findings,and rehabilitation course of a patient who developed rhabdomyolysis with peripheral nerve injury following combined quetiapine and alcohol intoxication were described in detail,and the relevant literature was reviewed. Results:A 14-year-old female was admitted with a 20-day history of bilateral lower limb weakness.Following quetiapine combined with alcohol intoxication,decreased muscle strength in both lower limbs developed,resulting in inability to stand or walk,and peripheral nerve damage in both lower limbs was indicated by electromyography.After two weeks of rehabilitation training,improvements were observed in the lower limb muscle strength,balance function,and activities of daily living.At two months after onset,the patient was able to stand with support between parallel bars for 30 min,and at one year,she was able to walk independently indoors with the aid of a walker. Conclusion:Although the mechanism underlying peripheral neuropathy caused by quetiapine intoxication remains unclear,functional recovery can be improved by early and intensive rehabilitation.关键词
喹硫平/中毒/横纹肌溶解/周围神经损伤/康复Key words
Quetiapine/Intoxication/Rhabdomyolysis/Peripheral neuropathy/Rehabilitation引用本文复制引用
向伟华,柳波,王培,陈文莉..喹硫平联合酒精中毒后出现横纹肌溶解合并周围神经损伤:1例报告及文献复习[J].神经病学与神经康复学杂志,2025,21(5):344-351,8.基金项目
江苏省卫生健康委科研课题(BJ24014) （BJ24014）
中大医院-连云港市第一人民医院联合基金项目(zdlyg15) （zdlyg15）
江苏省卫生国际交流项目 General Cadre Health Project of Jiangsu Provincial Health Commission(BJ24014) （BJ24014）
Joint Fund Project of Zhongda Hospital and Lianyungang First People's Hospital(zdlyg15) （zdlyg15）
Health International Exchange Program of Jiangsu Province （）
