神经病学与神经康复学杂志2025，Vol.21Issue(5)：368-375,8.DOI:10.12022/jnnr.2025-0228
多系统萎缩的机制及中西医诊疗进展
Mechanism of multiple system atrophy and progress in diagnosis and treatment with traditional Chinese and western medicine
摘要
Abstract
Multiple system atrophy(MSA)is a sporadic progressive neurodegenerative disease that is mainly categorized into Parkinsonism(MSA-P)and cerebellar(MSA-C)types.Its core clinical features include rapidly progressive autonomic failure and motor dysfunction.Currently,the etiology of MSA is unknown and involves multiple pathogenic mechanisms,therefore,treatment is limited to symptomatic management,and there is a lack of effective disease-modifying therapy(DMT)to slow down disease progression.Current research focuses on exploring diagnostic and therapeutic strategies combining traditional Chinese and western medicine,such as targeting α-synuclein pathology,regulating neuroinflammation,and enhancing neurotrophic support.Basic research and early clinical trials are evaluating the potential of various treatment options.This review aims to summarize the biological mechanisms of MSA and the latest research advancements,in order to facilitate clinical understanding of targeted treatment strategies for MSA.关键词
多系统萎缩/生物学机制/中医药/治疗Key words
Multiple system atrophy/Biologicall mechanism/Traditional Chinese medicine/Treatment引用本文复制引用
张宇晨,唐军..多系统萎缩的机制及中西医诊疗进展[J].神经病学与神经康复学杂志,2025,21(5):368-375,8.
