神经病学与神经康复学杂志2025，Vol.21Issue(5)：376-385,10.DOI:10.12022/jnnr.2025-0191
肠-脑轴在肌萎缩侧索硬化中的作用机制及中药干预研究进展
Progress on the mechanism of gut-brain axis in amyotrophic lateral sclerosis and intervention with traditional Chinese medicine
摘要
Abstract
Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease,and its pathogenesis is complex and has not been fully elucidated.In recent years,the dysregulation of the gut-brain axis(GBA)is considered to play an important role in the pathogenesis and progression of ALS.Intestinal microbiota and their metabolites,intestinal barrier function,immune system activation,and neuroinflammation communicate bidirectionally with the central nervous system through GBA,thereby influencing the pathological process of ALS.Meanwhile,various active components of Chinese herbal medicine have shown significant potential in regulating GBA function,improving gut microenvironment,and alleviate neuroinflammation.For instance,berberine can activate autophagy to clear TAR DNA-binding protein 43(TDP-43)aggregates;ginsenoside and its non-saponin component Gintonin can inhibit the TLR4-LPA1 signaling pathway to regulate neuroinflammatory responses;ligustrazine derivative tetramethylpyrazine nitrone(TMPN)can enhance the mitochondrial antioxidant function mediated by PGC1-α(peroxisome proliferator-activated receptor gamma coactivator 1-α);the 7,8-dihydroxyflavone(7,8-DHF)prodrug R13 can activate the TrkB-AMPK pathway to improve neuronal energy metabolism.This paper systematically reviews the mechanism of GBA in the pathogenesis and development of ALS,and focuses on discussing the potential mechanisms and research progress on Chinese herbal medicine interventions for ALS through the modulation of GBA function,aiming to provide new strategies and insights for ALS treatment.关键词
肠-脑轴/肠道微生物群/肌萎缩侧索硬化/作用机制/中药干预/研究进展Key words
Gut-brain axis/Gut microbiota/Amyotrophic lateral sclerosis/Action mechanism/Chinese herbal medicine intervention/Research progress引用本文复制引用
史金晶,滕晶,李甲民,李梦凡,管文慧,马浩腾..肠-脑轴在肌萎缩侧索硬化中的作用机制及中药干预研究进展[J].神经病学与神经康复学杂志,2025,21(5):376-385,10.基金项目
山东省重点研发计划项目(2021LCZX06) （2021LCZX06）
国家重点研发计划项目(2018YFC1707500) （2018YFC1707500）
山东中医药大学科研基金重点项目(KYZK2024Z02) Shandong Provincial Key Research and Development Program Project(2021LCZX06) （KYZK2024Z02）
National Key Research and Development Progam of China(2018YFC1707500) （2018YFC1707500）
Shandong University of Traditional Chinese Medicine Key Research Foundation(KYZK2024Z02) （KYZK2024Z02）
