神经病学与神经康复学杂志2025，Vol.21Issue(5)：386-395,10.DOI:10.12022/jnnr.2025-0201
中西医协同干预重症肌无力的免疫调控机制与研究进展
Immunoregulatory mechanism and research progress in integrated Chinse and western medicine for myasthenia gravis
摘要
Abstract
Myasthenia gravis(MG)is an autoimmune neuromuscular junction disorder mediated by pathogenic autoantibodies.Although modern medicine offers effective short-term symptom control,its long-term treatment is limited by adverse drug reactions,complications,and disease recurrence.Integrated traditional Chinese and western medicine(ICWM)has demonstrated potential advantages in the immunomodulatory treatment of MG.Various traditional Chinese medicine(TCM)monomers and compound prescriptions exert therapeutic effects through multiple mechanisms,including suppression of autoantibody production,regulation of cellular immune imbalance,inhibition of complement activation,and modulation of cytokine networks and signaling pathways.These actions help restore neuromuscular junction function and alleviating MG symptoms.Furthermore,combining TCM with conventional therapies may help reduce adverse reactions,enhance remission rates,and improve the patients'quality of life.This also provides new insights into personalized treatment strategies.However,current experimental and clinical research on ICWM for MG still requires further refinement and standardization to meet higher scientific rigor.关键词
中西医结合/干预/重症肌无力/免疫调控机制Key words
Integrated Chinese and western medicine/Intervention/Myasthenia gravis/Immunoregulatory mechanisms引用本文复制引用
曹丽平,萧凯俐,郑国庆..中西医协同干预重症肌无力的免疫调控机制与研究进展[J].神经病学与神经康复学杂志,2025,21(5):386-395,10.基金项目
贵州省科技计划项目[黔科合平台人才(2019)5602号] （2019）
贵州省科技创新人才建设[黔科合平台人才(2013)4034号] Guizhou Provincial Science and Technology Plan Project(Qian Ke He Platform Talent[2019]No.5602) （2013）
Guizhou Provincial Science and Technology Innovation Talent Construction[Qian Ke He Platform Talent(2013)No.4034] （2013）
