生物加工过程2025，Vol.23Issue(5)：491-500,10.DOI:10.3969/j.issn.1672-3678.2025.05.003
甘露糖磷酸酯钠对胶原蛋白生成及皮肤祛皱的影响
Effects of sodium mannose phosphate on collagen production and skin wrinkle removal
吴琳 1安志敏 2周琦 3吴啸宇 2魏军 4殷昊 4曾义安5
作者信息
- 1. 优然创新(北京)技术研发中心有限公司,北京 102206
- 2. 北京焉支山科技有限公司,北京 102206
- 3. 广州优然生物科技有限公司,广东 广州 510670
- 4. 优然创新(北京)技术研发中心有限公司,北京 102206||北京焉支山科技有限公司,北京 102206
- 5. 优然创新(北京)技术研发中心有限公司,北京 102206||北京焉支山科技有限公司,北京 102206||广州优然生物科技有限公司,广东 广州 510670
- 折叠
摘要
Abstract
This study aims to explore the effects of sodium mannosyl phosphate(M6P)on collagen production and skin wrinkle improvement.Both cell experiments and human efficacy evaluation experiments were applied in this case to evaluate the effects of M6P on the following functions:the proliferation activity of normal human dermal fibroblasts(NHDFs),the expression of collagen synthesis-related genes,the content of type I collagen,and skin wrinkle indicators in humans.As a result,the addition of M6P,at the concentration above 0.9 mg/L,significantly inhibited the growth of NHDFs cells.When the concentration of M6P was less than or equal to 0.9 mg/L,enhanced proliferation of NHDFs cells was observed,with the proliferation-promoting effect reaching the peak at M6P addition of 0.9 mg/L,at which point the relative content of type I collagen was the highest.In addition,M6P could up-regulate the expression of collagen synthesis-related genes(such as COL6A1,COL17A1,etc.)in NHDFs cells and significantly improve multiple indicators of skin tightness,elasticity,and eye corner wrinkles.In conclusion,M6P demonstrated effective promotion of collagen production,as well as reduction of skin wrinkles,providing a scientific basis for its application in the field of skin care.关键词
甘露糖磷酸酯钠/胶原蛋白/成纤维细胞/祛皱/化妆品Key words
sodium mannose phosphate/collagen/fibroblast/anti-wrinkle/cosmetics分类
生物工程引用本文复制引用
吴琳,安志敏,周琦,吴啸宇,魏军,殷昊,曾义安..甘露糖磷酸酯钠对胶原蛋白生成及皮肤祛皱的影响[J].生物加工过程,2025,23(5):491-500,10.
