陕西医学杂志2025，Vol.54Issue(11)：1485-1489,5.DOI:10.3969/j.issn.1000-7377.2025.11.008
呼气末二氧化碳分压、膈肌收缩速度、膈肌浅快呼吸指数与脓毒症患者机械通气撤机结局关系研究
Relationship between end-tidal carbon dioxide partial pressure,diaphragmatic contraction velocity,Diaphragmatic Rapid Shallow Breathing Index and the outcome of mechanical ventilation weaning in sepsis patients
摘要
Abstract
Objective:To investigate the relationship between end-tidal carbon dioxide partial pressure(PetCO2),diaphragmatic contraction velocity,Diaphragmatic Rapid Shallow Breathing Index(D-RSBI),and the outcome of me-chanical ventilation(MV)weaning in sepsis patients.Methods:A total of 80 sepsis patients who received MV treat-ment were selected and divided into two groups based on the outcome of weaning:the weaning failure group(29 cases)and the weaning success group(51 cases).The study compared PetCO2,D-RSBI index,and diaphragmatic contrac-tion velocity before and after spontaneous breathing trial(SBT)between the two groups.Multivariate logistic regres-sion analysis was used to identify factors influencing MV weaning failure in sepsis patients.ROC curves were plotted to analyze the predictive value of PetCO2,D-RSBI index,and diaphragmatic contraction velocity before SBT for MV weaning failure in sepsis patients.Results:Compared with the weaning success group,the weaning failure group had longer MV duration,higher APACHE Ⅱ score,higher SOFA score,higher respiratory rate(RR),higher heart rate before SBT,higher proportion of septic shock,and lower oxygenation index(all P＜0.05).The weaning failure group also had higher PetCO2 and D-RSBI index before SBT(all P＜0.05).Diaphragmatic contraction velocity before and after SBT was higher in the weaning success group(all P＜0.05).MV duration,severity of sepsis,diaphragmatic contraction velocity before SBT,D-RSBI index and PetCO2 were independent influencing factors for MV weaning fail-ure in sepsis patients(all P＜0.05).The AUC for predicting MV weaning failure in sepsis patients using the combi-nation of PetCO2,D-RSBI index,and diaphragmatic contraction velocity before SBT was higher than that of each fac-tor alone(all P＜0.05).Conclusion:PetCO2,diaphragmatic contraction velocity and D-RSBI index are associated with the outcome of MV weaning in sepsis patients,and combined detection has certain predictive value for MV weaning failure in sepsis patients.关键词
脓毒症/呼气末二氧化碳分压/膈肌收缩速度/膈肌浅快呼吸指数/机械通气/撤机/预测价值Key words
Sepsis/End-tidal carbon dioxide partial pressure/Diaphragmatic contraction velocity/Diaphragmatic Rapid Shallow Breathing Index/Mechanical ventilation/Weaning/Predictive value分类
医药卫生引用本文复制引用
王金娜,张国倩,毋利强,王芬,曲云云,陈旭萍,祁林..呼气末二氧化碳分压、膈肌收缩速度、膈肌浅快呼吸指数与脓毒症患者机械通气撤机结局关系研究[J].陕西医学杂志,2025,54(11):1485-1489,5.基金项目
山西省重点研发计划项目(2024SXZD12316) （2024SXZD12316）
