陕西医学杂志2025，Vol.54Issue(11)：1490-1494,5.DOI:10.3969/j.issn.1000-7377.2025.11.009
原发性急性闭角型青光眼患者房水中CXCR2、SDF-1、MCP-1水平变化及检测意义
Changes and detection significance of CXCR2,SDF-1 and MCP-1 levels in aqueous humor of patients with acute primary angle closure glaucoma
摘要
Abstract
Objective:To investigate the changes in the levels of CXC chemokine receptor 2(CXCR2),stromal cell-derived factor-1(SDF-1)and monocyte chemoattractant protein-1(MCP-1)in the aqueous humor of patients with acute primary angle closure glaucoma(APACG)and their detection significance.Methods:A total of 128 APACG patients undergoing trabeculectomy were selected as the APACG group,and 100 cataract patients(with nor-mal intraocular pressure)undergoing phacoemulsification during the same period were selected as the control group.The APACG patients were further divided into a successful surgery group(96 cases)and a failed surgery group(32 cases)based on the postoperative outcomes.The levels of CXCR2,SDF-1 and MCP-1 in the aqueous humor were de-tected using the ELISA method.Multivariate logistic regression analysis was used to identify the influencing factors of trabeculectomy failure in APACG patients,and ROC curves were used to analyze the predictive value of aqueous humor CXCR2,SDF-1 and MCP-1 for trabeculectomy failure.Results:Compared with the control group,the levels of CXCR2,SDF-1 and MCP-1 in the aqueous humor of the APACG group were significantly higher(all P＜0.05).There were no statistically significant differences in age,gender,onset time,preoperative number of glaucoma medica-tions,intraocular pressure,and postoperative number of intraocular pressure-lowering medications between the suc-cessful and failed surgery groups(all P＞0.05).The levels of CXCR2,SDF-1 and MCP-1 in the aqueous humor of the failed surgery group were higher than those in the successful surgery group(all P＜0.05).Aqueous humor CXCR2,SDF-1 and MCP-1 were identified as influencing factors for trabeculectomy failure in APACG patients(all P＜0.05).The AUC for predicting trabeculectomy failure using aqueous humor CXCR2,SDF-1,MCP-1 and their combination were 0.885,0.686,0.757 and 0.953,respectively,with the highest AUC for the combined prediction(all P＜0.05).Conclusion:Elevated levels of CXCR2,SDF-1 and MCP-1 in the aqueous humor of APACG patients are associated with trabeculectomy failure and have certain predictive value for it.关键词
原发性急性闭角型青光眼/CXC趋化因子受体2/基质细胞衍生因子-1/单核细胞趋化蛋白-1/小梁切除术/预测价值Key words
Acute primary angle closure glaucoma/CXC chemokine receptor 2/Stromal cell-derived factor-1/Monocyte chemoattractant protein-1/Trabeculectomy/Predictive value分类
临床医学引用本文复制引用
王慧琴,黄程华,邵文琼,杨硕,应充慧..原发性急性闭角型青光眼患者房水中CXCR2、SDF-1、MCP-1水平变化及检测意义[J].陕西医学杂志,2025,54(11):1490-1494,5.基金项目
国家自然科学基金资助项目(81700829) （81700829）
浙江省衢州市衢江区科技计划项目(QJ2024038) （QJ2024038）
