陕西医学杂志2025，Vol.54Issue(11)：1495-1499,5.DOI:10.3969/j.issn.1000-7377.2025.11.010
血清FOLR1、FABP4、SPOCK2与卵巢癌患者临床病理特征及预后关系研究
Relationship between serum FOLR1,FABP4,SPOCK2 and the clinical pathological characteristics and prognosis of ovarian cancer patients
摘要
Abstract
Objective:To investigate the relationship between serum folate receptor 1(FOLR1),fatty acid bind-ing protein 4(FABP4),SPARC/osteonectin,cwcv and kazal-like domains proteoglycan 2(SPOCK2)and the clinical pathological characteristics and prognosis of ovarian cancer(OC)patients.Methods:A total of 137 OC patients were selected as the OC group,and 100 healthy individuals were selected as the control group during the same period.The patients were followed up for 3 years and divided into two groups based on their survival status:the good prognosis group(95 cases)and the poor prognosis group(42 cases).The levels of serum FOLR1,FABP4 and SPOCK2 were compared among the groups.Multivariate logistic regression analysis was used to identify the influencing factors of poor prognosis in OC patients.The predictive value of serum FOLR1,FABP4 and SPOCK2 for the prognosis of OC patients was analyzed using ROC curves.Results:Compared with the control group,the levels of serum FOLR1,FABP4 and SPOCK2 were elevated in the OC group(all P＜0.05).There were significant differences in the levels of serum FOLR1,FABP4 and SPOCK2 among patients with different FIGO stages,tumor differentiation,lymph node metastasis and ascites(all P＜0.05).The poor prognosis group had a higher proportion of FIGO stage Ⅲ,lymph node metastasis,low tumor differentiation,and no lymph node dissection compared with the good prognosis group(all P＜0.05).The levels of serum FOLR1,FABP4 and SPOCK2 were higher in the poor prognosis group than in the good prognosis group(all P＜0.05).Serum FOLR1,FABP4 and SPOCK2 were identified as independent influ-encing factors for poor prognosis in OC patients(all P＜0.05).The AUC for predicting poor prognosis in OC pa-tients using serum FOLR1,FABP4 and SPOCK2 alone and in combination were 0.712,0.778,0.825 and 0.901,re-spectively,with the highest AUC for combined prediction(all P＜0.05).Conclusion:Elevated levels of serum FOLR1,FABP4 and SPOCK2 in OC patients are associated with clinical pathological characteristics and are inde-pendent factors for poor prognosis.Combined detection of these markers has predictive value for the prognosis of OC patients.关键词
卵巢癌/叶酸受体1/脂肪酸结合蛋白4/睾素2/临床病理特征/预后Key words
Ovarian cancer/FOLR1/FABP4/SPOCK2/Clinical pathological characteristics/Prognosis分类
临床医学引用本文复制引用
孙长江,陈丽,殷婷..血清FOLR1、FABP4、SPOCK2与卵巢癌患者临床病理特征及预后关系研究[J].陕西医学杂志,2025,54(11):1495-1499,5.基金项目
江苏省自然科学基金资助项目(BK20231329) （BK20231329）
