陕西医学杂志2025，Vol.54Issue(11)：1500-1504,5.DOI:10.3969/j.issn.1000-7377.2025.11.011
烧伤患者皮肤软组织扩张术后切口感染影响因素及血清Presepsin、PGE2检测意义
Influencing factors of incision infection after skin and soft tissue expansion in burn patients and the significance of serum Presepsin and PGE2 detection
摘要
Abstract
Objective:To explore the influencing factors of incision infection after skin and soft tissue expansion in burn patients and the significance of detecting serum Presepsin and prostaglandin E2(PGE2).Methods:A total of 260 burn patients who underwent skin and soft tissue expansion were selected.Patients were divided into the infection group(32 cases)and the non-infection group(228 cases)based on whether incision infection occurred after surgery.The distribution of pathogens in the infection group was detected.The levels of serum Presepsin and PGE2 were compared between the two groups.Multivariate logistic regression analysis was used to identify the influencing fac-tors of incision infection after skin and soft tissue expansion in burn patients.ROC curve analysis was used to evalu-ate the predictive value of serum Presepsin and PGE2 for postoperative incision infection in burn patients.Results:Among the 260 burn patients who underwent skin and soft tissue expansion,32 cases(12.30％)developed postoper-ative incision infection.A total of 40 pathogens were detected in the infection group,with 26 Gram-negative bacteria(65.00％)and 14 Gram-positive bacteria(35.00％).The infection group had longer surgical time,larger expander volume,and higher proportions of diabetes mellitus,inhalation injury,and internal placement of injection ports com-pared with the non-infection group(all P＜0.05).The levels of serum Presepsin and PGE2 were higher in the non-infection group than in the infection group(all P＜0.05).The influencing factors of incision infection after skin and soft tissue expansion in burn patients included diabetes mellitus,expander volume,and serum Presepsin and PGE2(all P＜0.05).The AUC for predicting incision infection after skin and soft tissue expansion in burn patients using serum Presepsin,PGE2 alone,and in combination were 0.773,0.805 and 0.912,respectively,with the highest AUC for combined prediction(all P＜0.05).Conclusion:Diabetes mellitus,expander volume,and serum Presepsin and PGE2 are influencing factors of incision infection after skin and soft tissue expansion in burn patients.Serum Presep-sin and PGE2 have certain predictive value for postoperative incision infection in these patients.关键词
烧伤/皮肤软组织扩张术/切口感染/影响因素/可溶性白细胞分化抗原14亚型/前列腺素E2Key words
Burn/Skin and soft tissue expansion/Incision infection/Influencing factors/Presepsin/Prostaglan-din E2分类
临床医学引用本文复制引用
彭敏,唐治琴,常东方..烧伤患者皮肤软组织扩张术后切口感染影响因素及血清Presepsin、PGE2检测意义[J].陕西医学杂志,2025,54(11):1500-1504,5.基金项目
重庆市自然科学基金资助项目(2021MSXM270) （2021MSXM270）
重庆市永川区自然科学基金资助计划项目(2023yc-jckx20018) （2023yc-jckx20018）
