实用医学杂志2025，Vol.41Issue(21)：3392-3397,6.DOI:10.3969/j.issn.1006-5725.2025.21.014
血清褪黑素、前列腺素2水平与早产儿坏死性小肠结肠炎病情及预后的关系
Relationship between serum melatonin,prostaglandin E2 levels and disease severity and prognosis in pre-mature infants with necrotizing enterocolitis
摘要
Abstract
Objective To investigate the relationship between serum melatonin and prostaglandin E2(PGE2)levels with disease severity and prognosis of necrotizing enterocolitis(NEC)in premature infants.Methods A total of 215 premature infants diagnosed with NEC(NEC group)admitted to our hospital between January 2022 and February 2025 and 80 healthy premature infants(control group)were prospectively enrolled.NEC cases were stratified by Bell's staging divided into mild(n=67),moderate(n=90),and severe(n=58)subgroups.Serum levels of melatonin and PGE2 were measured by enzyme-linked immunosorbent assay.Spearman correlation analysis was used to assess the relationship between serum melatonin,PGE2 levels and Bell staging.According to the 28-day prognosis assessment,NEC infants were divided into a poor prognosis group and a good prognosis group.Multivariate logistic regression and ROC analysis were used to explore the association and predictive value of serum melatonin and PGE2 levels in NEC prognosis,and decision curve analysis(DCA)was used to evaluate clinical net benefit.Results Compared with the control group,the NEC group had significantly lower serum melatonin levels and higher PGE2 levels(P<0.05).Among the NEC subgroups,serum melatonin levels decreased and PGE2 levels increased progressively from mild to severe NEC(P<0.05).Serum melatonin was negatively correlated with Bell stage,while PGE2 was positively correlated(P<0.05).The 28-day poor prognosis rate in NEC infants was 18.60%(40/215).Severe disease and elevated PGE2 were independent risk factors for poor prognosis,while higher birth weight and increased melatonin were independent protective factors(P<0.05).The area under the ROC curve(AUC)for predicting prognosis using melatonin,PGE2,and their combination was 0.797,0.780,and 0.880,respectively,with the combined prediction performing significantly better than either biomarker alone(P<0.05).DCA indicated that when the threshold probability exceeded 0.1,the net benefit of the combined model was greater than that of either marker alone.Conclusion In premature infants with NEC,reduced serum melatonin and elevated PGE2 levels are associated with increased disease severity and poor prognosis.The combination of serum melatonin and PGE2 levels provides high predictive value for prognosis.关键词
早产儿/坏死性小肠结肠炎/褪黑素/前列腺素2/病情/预后Key words
premature infant/necrotizing enterocolitis/melatonin/prostaglandin E2/disease severity/prognosis分类
临床医学引用本文复制引用
马云霞,张颖,刘丹..血清褪黑素、前列腺素2水平与早产儿坏死性小肠结肠炎病情及预后的关系[J].实用医学杂志,2025,41(21):3392-3397,6.基金项目
天津市卫生健康科技项目(编号:20ZXMFCY0076) （编号:20ZXMFCY0076）
