实用医学杂志2025，Vol.41Issue(21)：3455-3461,7.DOI:10.3969/j.issn.1006-5725.2025.21.023
以"肺-肠轴"理论分析参苓白术散加减与针刺联合对溃疡性结肠炎患者的影响
Analyzing the effects of the combination of ginseng-lingbaijusan plus reduction and acupuncture on patients with ulcerative colitis by the theory of"lung-intestinal axis"
摘要
Abstract
Objective Using the theory of the"lung-intestinal axis"to analyze the therapeutic efficacy of acupuncture combined with modified Ginseng-Ling-Bai-Zhu-San in patients with ulcerative colitis and its effects on intestinal flora balance.Methods One hundred and fifty patients with ulcerative colitis who received treatment at our hospital between October 2022 and December 2024 were enrolled in this study.These patients were randomly assigned to either the combination group or the control group,with 75 patients in each group.The control group was treated with modified Shenling Baizhu San,while the combination group received acupuncture in addition to the same herbal formula.After four treatment cycles,changes in TCM symptom scores,intestinal mucosal barrier func-tion,immune microenvironment,gut microbiota balance,and overall clinical efficacy were evaluated and compared between the two groups.Results Compared with the control group,the combination group showed significant improvements after treatment:TCM syndrome scores,IBDQ,DAI,Baron score,DAO,PCT,ET,IL-23,IL-6,IL-1β,CD8+,Enterobacteriaceae,Escherichia coli,Bifidobacterium bifidum,Th17/Treg ratio,and incidence of adverse reactions were significantly reduced;meanwhile,levels of Hb,ALB,PAB,TGF-β1,CD4+,CD4+/CD8+ratio,and Lactobacillus,as well as clinical efficacy,were markedly increased.All differences were statistically significant(P<0.05).Conclusion Effective and safe treatment of ulcerative colitis can be achieved through the combination of acupuncture and a modified formula of Ginseng-Ling-Bai-Juju-San,which may improve intestinal mucosal lesions,reduce inflammation,and stabilize the balance of intestinal flora by modulating the endocrine network of the"lung-intestinal axis".关键词
参苓白术散加减/基于"肺-肠轴"理论/针刺/溃疡性结肠炎/肠道菌群平衡Key words
ginseng ling baizhu san plus reduction/based on the theory of"lung-intestinal axis"/acu-puncture/ulcerative colitis/intestinal flora balance分类
临床医学引用本文复制引用
周欣,岳滨,柳越冬..以"肺-肠轴"理论分析参苓白术散加减与针刺联合对溃疡性结肠炎患者的影响[J].实用医学杂志,2025,41(21):3455-3461,7.基金项目
国家自然科学基金项目(编号:82074449) （编号:82074449）
辽宁省科学技术计划项目(编号:2024-MS-18) （编号:2024-MS-18）
