摘要
Abstract
Objectives:To compare the clinical outcomes of three different controlled ovarian stimulation(COS)protocols,namely luteal phase long protocol,antagonist protocol,and follicular phase long protocol,in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET)for patients with normal ovarian reserve function.
Methods:A retrospective analysis of clinical data from 552 cycles of patients with normal ovarian reserve who underwent IVF/ICSI-ET treatment at the Centre of Reproductive Medicine of Affiliated Hospital of Putian University from January 2019 to December 2023 was conducted.Patients were grouped according to different COS protocols:luteal phase long protocol group(group A,177 cycles),antagonist protocol group(group B,291 cycles),follicular phase long protocol group(group C,84 cycles).The general information,COS medication and oocyte retrieval,embryo development and embryo transfer,and pregnancy outcomes were compared among the three groups.
Results:There were no significant differences in age,body mass index(BMI)and infertility duration among the three groups(P＞0.05).The total amount and duration of gonadotropin(Gn)used in group C were significantly higher than those in groups A and B(P＜0.01).The endometrial thickness,follicle stimulating hormone(FSH)level,and oocyte retrieval rate on human chorionic gonadotropin(HCG)day were significantly higher in group C than those in groups A and B(P＜0.01).The estradiol(E2)level,luteinizing hormone(LH)level,and the number of follicles with a diameter ≥14 mm on HCG day were significantly lower in group C than those in groups A and B(P＜0.01).The number of D3 high-quality embryos,blastocyst formation rate,and high-quality blastocyst formation rate in group B were significantly higher than those in group C(P＜0.05),and the available embryo rate and D3 high-quality embryo rate were significantly higher than those in groups A and C(P＜0.05).There were 54,103 and 33 fresh embryo transfer cycles in group A,B and C respectively.There were no significant differences in the number of transferred embryos,fresh embryo implantation rate,clinical pregnancy rate,early miscarriage rate,and the incidence of moderate to severe ovarian hyperstimulation syndrome among 3 groups(P＞0.05).
Conclusions:The luteal phase long protocol,antagonist protocol,and follicular phase long protocol can all be used for patients with normal ovarian reserve function,but the use of antagonist protocol for COS can reduce the total amount and duration of Gn use,and achieve better embryo development.However,no significant differences in pregnancy outcomes were found among three protocols for fresh embryo transfer.关键词
黄体期长方案/拮抗剂方案/卵泡期长方案/体外受精-胚胎移植/临床结局Key words
Luteal phase long protocol/Antagonist protocol/Follicular phase long protocol/In vitro fertilization-embryo transfer/Clinical outcome分类
临床医学
