生殖医学杂志2025，Vol.34Issue(10)：1359-1365,7.DOI:10.3969/j.issn.1004-3845.2025.10.009
PCOS患者肠道菌群水平与糖代谢的关系及对PCOS伴胰岛素抵抗的预测价值
The relationship between gut microbiota levels and glucose metabolism in PCOS patients and its predictive value for PCOS with insulin resistance
摘要
Abstract
Objectives:To explore the relationship between gut microbiota levels and glucose metabolism in patients with polycystic ovary syndrome(PCOS)and its predictive value for PCOS with insulin resistance(IR). Methods:A total of 102 patients with PCOS admitted to Nantong Maternal and Child Health Hospital from July 2022 to July 2024 were selected as the study group,and 105 healthy subjects in the same hospital during the same period were selected as the control group.All subjects were tested for gut microbiota level.According to whether the patients in the study group were accompanied by IR,they were divided into two subgroups as IR group(n=61)and non-IR group(n=41).The glucose metabolism indexes were measured,and the correlation between the level of gut microbiota and glucose metabolism indexes in the study group,the influencing factors of PCOS with IR,and the predictive efficacy of gut microbiota level for PCOS with IR were analyzed. Results:The body mass index(BMI),Enterococcus and Enterobacter in the study group were higher than those in the control group(P＜0.05),and the levels of Bifidobacterium and Lactobacillus were lower than those in the control group(P＜0.05).The levels of Enterobacter,glycated hemoglobin,fasting blood glucose,fasting insulin(FINS),BMI,triglycerides(TG)and testosterone(T)in the IR group were higher than those in the non-IR group,while the levels of Bifidobacterium,Lactobacillus and high-density lipoprotein cholesterol(HDL-C)were lower than those in the non-IR group(P＜0.05).The logistic results showed that the levels of Enterobacter[OR=2.754,95％CI(1.693,4.478)],Bi fidobacterium[OR=0.265,95％ CI(0.128,0.561)]and Lactobacillus[OR=0.251,95％CI(0.134,0.469)],FINS[OR=4.046,95％CI(2.369,6.908)]and HDL-C[OR=0.203,95％CI(0.074,0.557)]were independent influencing factors of IR in PCOS patients(P＜0.05).The receiver operating characteristic curve showed that the area under the curve(AUC)of Enterobacterium,Bifidobacterium,Lactobacillus and the combination of the above three to predict PCOS with IR was 0.786,0.797,0.800 and 0.912,respectively(P＜0.05).Pearson analysis showed that the FINS level in PCOS patients was negatively correlated with Bifidobacterium and Lactobacillus levels,while positively correlated with Enterobacterium level(P＜0.05). Conclusions:The level of gut microbiota in PCOS patients is related to the level of glucose metabolism.The levels of Enterobacter,Bifidobacterium and Lactobacillus have a certain predictive value for PCOS with IR,and the detection efficiency of combination of the above three is high.关键词
多囊卵巢综合征/肠道菌群/胰岛素抵抗/糖代谢/预测价值Key words
Polycystic ovary syndrome/Gut microbiota/Insulin resistance/Glucose metabolism/Predictive value分类
医药卫生引用本文复制引用
卢清,曾莉,丁易钤,石城,吴艳婷..PCOS患者肠道菌群水平与糖代谢的关系及对PCOS伴胰岛素抵抗的预测价值[J].生殖医学杂志,2025,34(10):1359-1365,7.基金项目
江苏省自然科学基金项目(BK20211057) （BK20211057）
2022年度南通市卫生健康委员会科研课题立项项目(QNZ2022041) （QNZ2022041）
