妇儿健康导刊2025，Vol.4Issue(20)：109-113,5.DOI:10.3969/j.issn.2097-115X.2025.20.021
初乳口腔免疫疗法对早产儿肠道菌群的影响
Effect of colostrum oral immunotherapy on the intestinal flora of premature infants
摘要
Abstract
Objective To observe the effect of colostrum oral immunotherapy on the intestinal flora of premature infants.Methods A total of 70 premature infants admitted to Zhuhai Center for Maternal and Child Health Care from July 2023 to January 2025 were selected as the study subjects.They were divided into two groups using a random number table method,with 35 cases in each group.The control group received oral drip of physiological saline,while the observation group received colostrum oral immunotherapy.The intestinal flora,incidence of complications,antibiotic use and clinically relevant indicators of the two groups were compared.Results After the intervention,the concentrations of Lactobacillus and Bifidobacterium in the observation group were higher than those in the control group(P<0.05).The incidence of late-onset septicemia,necrotizing enterocolitis and ventilator-associated pneumonia in the observation group was lower than that in the control group(P<0.05).The usage time of restricted grade and special restricted grade antibiotics in the observation group was shorter than that in the control group(P<0.05).The average weight gain rate of the observation group was higher than that of the control group,the age at which weight began to increase,the age at which birth weight was reached,and the age at which complete oral feeding was reached were younger than those of the control group,the mechanical ventilation time and hospital stay were shorter than those of the control group,and the incidence of feeding intolerance was lower than that of the control group(P<0.05).Conclusion The implementation of colostrum oral immunotherapy for premature infants can regulate the intestinal flora,prevent infectious diseases,reduce the use of antibiotics,and promote growth and development,which is worthy of promotion.关键词
早产儿/初乳口腔免疫疗法/肠道菌群Key words
Premature infant/Colostrum oral immunotherapy/Intestinal flora分类
临床医学引用本文复制引用
高子莹,陈非,王盼锡,甘仙云..初乳口腔免疫疗法对早产儿肠道菌群的影响[J].妇儿健康导刊,2025,4(20):109-113,5.基金项目
广东省珠海市医学科研项目(2220009000255). （2220009000255）
