无机材料学报2025，Vol.40Issue(10)：1137-1144,8.DOI:10.15541/jim20250030
近红外光响应的双相抗菌介孔生物活性玻璃复合支架的制备及抗菌性能研究
Near-infrared Responsive Biphasic Antibacterial Mesoporous Bioactive Glass Composite Scaffolds:Preparation and Antibacterial Performance
摘要
Abstract
Bone implant-related infections are characterized by a high risk of delayed incidence or recurrence.Current antibacterial strategies often lack selectivity,leading to collateral damage to normal tissues and cells during bacterial eradication.To address this,mesoporous bioactive glass(MBG)was used as a base material in this study.By leveraging the near-infrared(NIR)photothermal response of S-NO bonds to release NO radicals and the antibacterial properties of Cu2+,MBG-RSNO powder was synthesized through amino-functionalized conjugation of S-nitrosothiols(RSNO)for nitric oxide free radicals(NO·)delivery,while PMBG@Cu powder was prepared via dopamine polymerization and Cu2+chelation.These two powder materials were further processed through 3D printing to fabricate a PMBG@Cu/MBG-RSNO composite antibacterial scaffold.This scaffold demonstrated a strong NIR photothermal response,with pulsed 808 nm laser irradiation enabling the sustained release of NO·up to 113.71 μg per 100 mg of MBG-RSNO and increasing the temperature to approximately 40℃,facilitating efficient bacterial elimination.Antibacterial performance of the scaffold was evaluated using Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli)as representative Gram-positive and Gram-negative bacteria,respectively,with and without external NIR stimulation.The results revealed that the PMBG@Cu/MBG-RSNO composite scaffold achieved an antibacterial efficiency of 99.9％against both bacterial strains.In summary,the PMBG@Cu/MBG-RSNO composite scaffold offers a promising solution to address infection challenges in bone implant materials and supports bone defect repair.关键词
介孔生物活性玻璃/抗菌/一氧化氮/光热效应Key words
mesoporous bioactive glass/antibacterial/nitric oxide/photothermal effect分类
化学工程引用本文复制引用
张博,付一敏,陈政,石澳,朱敏..近红外光响应的双相抗菌介孔生物活性玻璃复合支架的制备及抗菌性能研究[J].无机材料学报,2025,40(10):1137-1144,8.基金项目
国家自然科学基金(52072246)National Natural Science Foundation of China(52072246) （52072246）
