无机材料学报2025，Vol.40Issue(10)：1145-1152,8.DOI:10.15541/jim20250078
Mn/nHA涂层CF/PEEK复合材料的制备及体外成骨活性评价
Preparation and in vitro Osteogenic Activity Evaluation of Mn/nHA Coated CF/PEEK Composite
摘要
Abstract
Carbon fiber/polyetheretherketone(CF/PEEK)has been widely used in the field of bone repair.However,its bio-inert nature results in poor osseointegration,which significantly limits its long-term stability and bone repair efficacy in clinical applications.Here,a manganese-doped nano-hydroxyapatite(Mn/nHA)coating was constructed on the surface of CF/PEEK using a liquid-phase self-assembly strategy of inorganic nanoparticles.The experimental results demonstrated that both Mn/nHA and nHA coatings significantly improved the surface roughness and hydrophilicity of CF/PEEK.Further in vitro studies revealed that after co-culturing with rat mesenchymal stem cells(BMSCs)for 7 d,the relative cell viability of the Mn/nHA-and nHA-coated materials reached as high as 180％and 159％,respectively,indicating a pronounced pro-proliferative effect.Additionally,alizarin red staining and reverse transcription-polymerase chain reaction(RT-PCR)analysis showed that both coatings enhanced cell mineralization and osteogenic differentiation on the material surface,with the Mn/nHA coating exhibiting a stronger promoting effect.关键词
羟基磷灰石/锰/碳纤维/聚醚醚酮/成骨活性Key words
hydroxyapatite/manganese/carbon fiber/polyetheretherketone/osteogenic activity分类
基础医学引用本文复制引用
李正浩,李婧鸣,章玉祥,袁波,张凯,朱向东..Mn/nHA涂层CF/PEEK复合材料的制备及体外成骨活性评价[J].无机材料学报,2025,40(10):1145-1152,8.基金项目
国家重点研发计划(2022YFC2406102)National Key R&D Program of China(2022YFC2406102) （2022YFC2406102）
