畜牧兽医学报2025，Vol.56Issue(10)：4759-4773,15.DOI:10.11843/j.issn.0366-6964.2025.10.001
整合eQTL和GWAS数据识别潜在功能基因位点在动物遗传育种中的研究进展
Research Progress on Integrated eQTL-GWAS Data Analysis for Potential Functional Genetic Loci Identification in Animal Breeding
摘要
Abstract
Accurately identifying the potential functional genetic loci that significantly associated with animal economic traits holds both theoretical and practical significance for improving individ-ual animal breeding outcomes and enhancing production performance.With the advancement of omics technologies,integrating multi-omics information has become an effective strategy to en-hance the precision of genetic locus identification.Among these,expression quantitative trait lo-cus(eQTL)analysis provides a new research perspective for analyzing the association mecha-nisms between genotypes and economic traits,as well as the genetic regulatory networks of gene expression,making it an important research direction in the post-genome-wide association study(Post-GWAS)era.This paper first introduces the basic principles and methods of eQTL analy-sis,then focuses on strategies and approaches for integrating eQTL and GWAS data to enhance the efficiency of functional genetic loci identification,as well as its applications in the genetic breeding of important livestock(cattle,pigs,chickens and sheep).Finally,it summarizes the problems that exist in practical implementation,which provides theoretical foundations for eluci-dating the genetic architecture of complex traits in animals and establishes a crucial basis for ad-vancing innovative biobreeding technologies to revitalize the livestock breeding industry.关键词
eQTL/GWAS/功能基因位点/动物育种Key words
eQTL/GWAS/functional genetic loci/animal breeding分类
农业科技引用本文复制引用
曹雨,王志英,周铂涵,许琦,袁子翱,苏蕊,吕琦,李金泉,张燕军,王瑞军..整合eQTL和GWAS数据识别潜在功能基因位点在动物遗传育种中的研究进展[J].畜牧兽医学报,2025,56(10):4759-4773,15.基金项目
2030科技创新-重大项目(2023ZD0405102) （2023ZD0405102）
内蒙古自治区科技计划(2023KYPT0021) （2023KYPT0021）
内蒙古自治区教育厅一流学科科研专项重点项目(YLXKZX-NND-007) （YLXKZX-NND-007）
2024鄂尔多斯市标志性创新团队(TD20240001) （TD20240001）
财政部和农业农村部:国家绒毛用羊产业技术体系(CARS-39) （CARS-39）
羊遗传资源保护与创新利用(BR251201) （BR251201）
