畜牧兽医学报2025，Vol.56Issue(10)：4839-4850,12.DOI:10.11843/j.issn.0366-6964.2025.10.007
玉米赤霉烯酮内酯水解酶的研究及其在畜禽日粮中的应用
The Research on Zearalenone Lactonase and Its Application in Livestock and Poultry Diets
摘要
Abstract
Zearalenone(ZEN)and its derivatives rank among the most hazardous mycotoxins worldwide,posing a significant threat to food safety and public health.Consequently,the devel-opment of efficient biodegradation strategies for ZEN has emerged as a critical research priority.Among these,enzymatic degradation approaches have garnered considerable attention due to their specificity and efficacy.ZEN-degrading enzymes primarily include laccases,manganese peroxida-ses,and lactonases.Compared to the first two enzyme classes,lactonases exhibit distinct advan-tages for the development of ZEN detoxification agents,including higher catalytic activity,well-defined degradation mechanisms,and non-toxic degradation byproducts.However,natural en-zymes often suffer from limited stability under industrial processing conditions,hindering their applicability in large-scale production and practical settings.To address this challenge,enhancing enzyme activity and stability through rational or semi-rational design and optimization has become a key research focus.This review comprehensively examines microbial-derived ZEN lactonases,covering gene mining,biochemical characterization,molecular engineering,and practical applica-tions.By evaluating the advantages and limitations of biological detoxification in industrial and livestock production,this analysis provides novel insights for the development of highly active,robust ZEN-detoxifying enzyme preparations.关键词
玉米赤霉烯酮/内酯水解酶/理性设计/酶活稳定性/稳定性优化/毒素降解Key words
zearalenone/lactonase/rational design/enzyme activity stability/stability optimiza-tion/toxin degradation分类
农业科技引用本文复制引用
俞良诚,孙博,任曼,闫雪,刘宽博,宋佳,岳隆耀,王薇薇,赵晨..玉米赤霉烯酮内酯水解酶的研究及其在畜禽日粮中的应用[J].畜牧兽医学报,2025,56(10):4839-4850,12.基金项目
中央级公益性科研院所基本科研业务费项目(ZX2421) （ZX2421）
