心脑血管病防治2025，Vol.25Issue(9)：41-45,5.DOI:10.3969/j.issn.1009-816x.2025.09.009
巨噬细胞在动脉粥样硬化发生机制中的作用
The role of macrophages in the pathogenesis of atherosclerosis
杨茜雅 1顾嘉静 1毛若馨 1陈钰丹 1陈欣怡 1麦一峰1
作者信息
- 1. 315020 宁波,宁波大学附属第一医院
- 折叠
摘要
Abstract
Atherosclerosis(AS)is a chronic vascular disease and an important pathological basis for cardiovascular and cerebrovascular diseases.Macrophages play a dual role in occurrence and progression of AS:on one hand,they exacerbate AS through pathological processes such as promoting inflammatory responses,oxidative stress,and ferroptosis;on the other hand,the efferocytosis helps maintain plaque stability by eliminating apoptotic cells and inhibiting the spread of local inflammation.A systematic analysis of the multidimensional functions of macrophages in AS and the regulatory mechanism will provide a new theoretical foundation for disease prevention and treatment,and lay the groundwork for developing precise intervention strategies and clinical translation.关键词
巨噬细胞/动脉粥样硬化/炎症/铁死亡/胞葬作用Key words
Macrophages/Atherosclerosis/Inflammation/Ferroptosis/Efferocytosis引用本文复制引用
杨茜雅,顾嘉静,毛若馨,陈钰丹,陈欣怡,麦一峰..巨噬细胞在动脉粥样硬化发生机制中的作用[J].心脑血管病防治,2025,25(9):41-45,5.
