眼科新进展2025，Vol.45Issue(11)：888-896,9.DOI:10.13389/j.cnki.rao.2025.0153
中医药治疗干眼的循证证据评价研究
Evaluation of the evidence-based medicine of traditional Chinese medicine in the treatment of dry eye
摘要
Abstract
Objective This study aims to systematically evaluate the evidence-based medicine of traditional Chinese medicine(TCM)in the treatment of dry eye,analyze its efficacy and differences compared with modern Western medicine treatments,and provide a scientific basis for clinical application.Methods By searching Chinese and English databases(including CNKI,Wanfang Data,PubMed,Cochrane Library,etc.),we included meta-analyses and systematic reviews of TCM treatments for dry eye.Literature was screened according to strict inclusion and exclusion criteria,and relevant data were extracted and integrated for analysis.The Mantel-Haenszel fixed-effects model was used to calculate the relative risk(RR)and mean difference(WMD),with the effect size expressed as a 95％confidence interval,to analyze the efficacy in-dicators of TCM treatment for dry eye.Results A total of 21 articles were finally included,involving various TCM inter-ventions for dry eye(such as Chinese herbal medicine,acupuncture,and TCM external therapies).The results showed that TCM treatment was superior to Western medicine alone in improving the overall clinical efficacy[RR=1.63,95％CI(1.46,1.81),P＜0.05],prolonging tear film break-up time[MD=2.23,95％CI(1.85,2.60),P＜0.05],and increasing tear secretion[MD=1.49,95％CI(1.04,1.94),P＜0.05].In addition,acupuncture,the combination of Chinese herbal medicine and Western medicine,and TCM external therapies all demonstrated unique advantages in improving dry eye symptoms and tear function.Conclusion TCM treatment for dry eye shows significant efficacy in key indicators such as overall clinical efficacy,tear film break-up time,and tear secretion,with a high level of safety.关键词
中医药/干眼/循证证据评价Key words
traditional Chinese medicine/dry eye/evaluation of evidence-based evidence分类
临床医学引用本文复制引用
令娟,杨芮,康莉,雷迅文,罗向霞,韩雪,胡梅,杨雪,李嘉进,代明丽,庄家园,高英,胡亦明..中医药治疗干眼的循证证据评价研究[J].眼科新进展,2025,45(11):888-896,9.基金项目
国家自然科学基金项目(编号:8236150800) （编号:8236150800）
甘肃省自然科学基金项目(编号:24JRRA566) （编号:24JRRA566）
甘肃省省级人才项目[编号:甘组通字(2024)4号] （2024）
甘肃省高校研究生"创新之星"项目(编号:2025CXZX-911) （编号:2025CXZX-911）
甘肃省科技计划项目优秀博士生项目(编号:24JRRA614) （编号:24JRRA614）
甘肃省拔尖领军人才项目[编号:省委人才小组发(2024)12号] （2024）
甘肃省药品监督管理局科研项目(编号:2025GSMPA064) （编号:2025GSMPA064）
甘肃省名中医罗向霞传承工作室建设项目 （）
