眼科新进展2025，Vol.45Issue(11)：902-907,6.DOI:10.13389/j.cnki.rao.2025.0155
靶向神经胶质细胞的青光眼相关视神经保护策略
Glial cell-targeted strategies for optic nerve protection in glaucoma
摘要
Abstract
Glial cells play a central role in maintaining retinal homeostasis and supporting neuronal function.Under glaucomatous pathological conditions,glial cells become activated in response to neuronal injury,exhibiting a protective bi-as in the early stages while tending to exacerbate damage in the later stages.With in-depth research on the pathogenesis of glaucoma,neuroprotective strategies are gradually shifting from the traditional neuron-centered paradigm to a new para-digm of neuron-glia co-intervention.Targeting the pathological changes in glial cell function and structure,researchers aim to mitigate excitotoxicity and inflammatory damage,optimize energy metabolism,improve tissue remodeling,and reduce myelin loss,thereby protecting retinal ganglion cells.This article reviews recent research progress in providing optic nerve protection through interventions targeting glial cells.These advancements have promoted the development of non-intraocu-lar pressure-dependent neuroprotective strategies.关键词
神经节细胞/神经胶质细胞/神经保护/青光眼Key words
ganglion cells/glial cells/neuroprotection分类
临床医学引用本文复制引用
蔡唐人,雷林旖,姚进..靶向神经胶质细胞的青光眼相关视神经保护策略[J].眼科新进展,2025,45(11):902-907,6.基金项目
国家自然科学基金项目(编号:82271107) （编号:82271107）
江苏省自然科学基金项目(编号:BK20221186) （编号:BK20221186）
江苏省卫生健康委员会重点项目(编号:K2023060) （编号:K2023060）
