眼科新进展2025，Vol.45Issue(11)：919-924,6.DOI:10.13389/j.cnki.rao.2025.0158
山奈酚在眼科疾病治疗中的作用研究进展
Research progress on the application of kaempferol in ophthalmology
摘要
Abstract
Kaempferol(KAE),as a natural flavonoid compound,possesses multiple biological activities including po-tent anti-inflammatory,antioxidant,and immunomodulatory effects,as well as anti-cancer properties.It has demonstrated good therapeutic effects in the intervention and treatment of various ocular diseases such as fungal keratitis,corneal trans-plantation rejection,age-related macular degeneration,and diabetic retinopathy.Furthermore,the development of novel ocular drug delivery systems-such as KAE-loaded bovine serum albumin porous membranes,KAE eye drops based on poly-vinylpyrrolidone nanocomplexes,gelatin nanoparticles encapsulating KAE,and platelet-derived extracellular vesicles loaded with KAE-has improved the bioavailability of KAE,laying a foundation for expanding its applications.However,there is a lack of systematic and comprehensive reviews on the application of KAE in ophthalmic diseases.Therefore,this article summarizes the research progress,efficacy mechanisms,and novel delivery methods of KAE in ophthalmic diseases,ai-ming to provide new diagnostic and therapeutic strategies for the treatment of related ocular conditions.关键词
山奈酚/眼科疾病/抗氧化/抗炎/免疫调节Key words
kaempferol/ophthalmic diseases/antioxidant/anti-inflammatory/immunomodulation分类
临床医学引用本文复制引用
杨靖怡,王高蕾,郭滨,毕宏生..山奈酚在眼科疾病治疗中的作用研究进展[J].眼科新进展,2025,45(11):919-924,6.基金项目
山东省自然科学基金项目(编号:ZR2020MH393) （编号:ZR2020MH393）
山东中医药大学临床科研专项(编号:LCKY202432) （编号:LCKY202432）
