摘要
Abstract
Objective Most patients with chronic insomnia depend on long-term medication,which may easily lead to a poor treatment outcome and adverse drug reactions,and transcranial alternating current stimulation(tACS),as a noninvasive neuromodulation technique,can improve chronic insomnia.This study aims to investigate the clinical efficacy of tACS combined with pharmacotherapy in the treatment of chronic insomnia.Methods A total of 46 patients with chronic insomnia were enrolled and randomly divided into pharmacotherapy group with 20 patients and pharmacotherapy+tACS treatment group with 26 patients.The tACS electrodes were attached to the frontal region and the bilateral mastoids,with a frequency of 77.5 Hz and a current intensity of 15 mA,for 40 minutes each time,once a day for 10 consecutive days.The primary outcome measures were Pittsburgh Sleep Quality Index(PSQI)score and its improvement rate after 4 weeks,and the sec-ondary outcome measures included the scores of Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Rating Scale(HAMA),Mini-Mental State Examination(MMSE),and Montreal Cognitive Assessment(MoCA)and their improvement rates.Results Compared with the pharmacotherapy group,the pharmacotherapy+tACS treatment group had a significant reduction in PSQI score(P<0.05),with an improvement rate of 37%and 21%,respectively,suggesting that the combined therapy had a bet-ter effect in improving sleep quality.The pharmacotherapy+tACS treatment group also had reductions in HAMA and HAMD scores,suggesting improvements in anxiety and depression symptoms,and there were no significant differences in MMSE and MoCA scores between the two groups.Conclusion Pharmacotherapy combined with tACS has a better effect than pharmaco-therapy alone in improving sleep quality and anxiety and depression symptoms in patients with chronic insomnia,and therefore,it has good application prospects in clinical practice.关键词
慢性失眠/经颅交流电刺激/焦虑抑郁/认知功能Key words
Chronic insomnia/Transcranial alternating current stimulation/Anxiety and depression/Cogni-tive function分类
医药卫生
