中风与神经疾病杂志2025，Vol.42Issue(10)：886-889,4.DOI:10.19845/j.cnki.zfysjjbzz.2025.0164
肠道菌群失调在Ⅰ型发作性睡病中的作用
Role of gut microbiota dysbiosis in narcolepsy type 1
摘要
Abstract
Narcolepsy(NP)is a rare nervous system disease with the typical symptoms of excessive daytime sleepi-ness,cataplexy,sleep paralysis,and hypnagogic hallucination.The pathophysiological mechanism of NP remains un-clear,and it is currently believed that NP is an immune-related disease closely associated with HLA-DQB1*06∶02 geno-type and it can be triggered by environmental factors such as infection and vaccination,while the precise neural pathways leading to degeneration/apoptosis of orexin neurons in the lateral hypothalamic area remain unknown.In recent years,an increasing number of evidence has revealed the association between sleep disturbance and gut microbiota,and in particu-lar,the microbiota-gut-brain axis plays an important role in sleep regulation.This article systematically reviews the regula-tory mechanism of gut microbiota in the central nervous system and discusses the potential interaction between gut micro-biota and NP,in order to provide new perspectives for both mechanistic research and clinical management of NP.关键词
发作性睡病/日间过度思睡/猝倒/肠道菌群/微生物-肠-脑轴Key words
Narcolepsy/Excessive daytime sleepiness/Cataplexy/Gut microbiota/Microbiota-gut-brain axis分类
医药卫生引用本文复制引用
赵倩,张红菊..肠道菌群失调在Ⅰ型发作性睡病中的作用[J].中风与神经疾病杂志,2025,42(10):886-889,4.基金项目
河南省科技发展计划项目(252102311152) （252102311152）
