中风与神经疾病杂志2025，Vol.42Issue(10)：916-921,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0169
血管紧张素转化酶抑制剂在脑出血后康复中的作用及其分子机制研究
Role and molecular mechanism of angiotensin-converting enzyme inhibitor in rehabilitation after cerebral hemorrhage
摘要
Abstract
Objective To investigate the role and molecular mechanism of angiotensin-converting enzyme inhibitor(ACEI)in rehabilitation after cerebral hemorrhage through a comparative analysis with a control group.Methods A total of 50 patients with cerebral hemorrhage were divided into observation group and control group for comparison.The patients in the observation group received ACEI treatment,while those in the control group received conventional treatment.The two groups were compared in terms of neurological function,brain imaging findings,blood biochemical parameters,and molecular mechanism indicators.Results At the beginning of treatment,there were no significant differences in the above indicators between the observation group and the control group.During the treatment process,the observation group showed significant advantages in neurological function assessment,brain imaging findings,and blood biochemical param-eters.Compared with the control group after 1 week of treatment,the observation group had significantly lower neurologi-cal function score,absorption rate of cerebral hemorrhagic foci,blood pressure,blood glucose,and blood lipids(P<0.001).Molecular mechanism indicators showed that compared with the control group,the observation group had sig-nificantly lower levels of angiotensin Ⅱ,neuroinflammatory factors,and neuronal apoptosis-related proteins(P<0.001).Conclusion ACEI significantly promotes rehabilitation after cerebral hemorrhage and can improve neurological func-tion,promote the absorption of cerebral hemorrhagic foci,and regulate blood pressure and the metabolism of blood glucose and blood lipids,and meanwhile,ACEI can exert a neuroprotective effect through multiple molecular mechanisms.There-fore,ACEI may become one of the effective drugs for the rehabilitation of cerebral hemorrhage.关键词
脑出血/血管紧张素转化酶抑制剂/神经保护/分子机制Key words
Cerebral hemorrhage/Angiotensin-converting enzyme inhibitor/Neuroprotection/Molecular mechanisms分类
医药卫生引用本文复制引用
张敏,王强,王萃..血管紧张素转化酶抑制剂在脑出血后康复中的作用及其分子机制研究[J].中风与神经疾病杂志,2025,42(10):916-921,6.基金项目
衡水市科技计划项目(2020014067Z) （2020014067Z）
