中风与神经疾病杂志2025，Vol.42Issue(10)：922-927,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0170
β2微球蛋白与脑白质高信号严重程度的相关性及其预测价值
Association between β2-microglobulin and the severity of white matter hyperintensities and the predictive value of β2-microglobulin
摘要
Abstract
Objective To investigate the association between serum β2-microglobulin(β2M)and the severity of white matter hyperintensities(WMHs)in patients with cerebral small vessel disease(CSVD),as well as the value of β2M in predicting the severity of WMHs.Methods This study was conducted among the patients who were consecutively ad-mitted to The Second People's Hospital of Hefei from December 2021 to April 2024 and whose cranial MRI findings were consistent with the radiological features of WMHs.The Fazekas scale was used to assess the severity of periventricular white matter hyperintensities(PWMHs)and deep white matter hyperintensities(DWMHs).According to the sum of the scores of the above two regions,the patients with 0‒2 points were enrolled as none or mild WMHs group,and those with 3-6 points were enrolled as moderate or severe WMHs group;according to a difference of≥1 point between the scores of the two regions,the patients were divided into predominant PWMHs(pred-PWMHs)subgroup and predominant DWMHs(pred-DWMHs)subgroup,and each subgroup was further divided into mild group(with a Fazekas score of 1 point)and moderate or severe group(with a Fazekas score of 2‒3 points).The univariate and multivariate logistic regression analyses were used to identify independent risk factors for overall WMHs,PWMHs,and DWMHs.The receiver operating charac-teristic(ROC)curve was plotted to assess the value of β2M in predicting moderate or severe overall WMHs.Results A total of 346 patients were enrolled in the study.The univariate analysis showed that age,hypertension,fibrinogen,homocyste-ine,cystatin C,total cholesterol,low-density lipoprotein cholesterol,eGFR,and β2M were associated with the severity of WMHs(all P<0.05),and the multivariate logistic regression analysis showed that age,hypertension,and β2M were inde-pendent risk factors for moderate or severe WMHs(all P<0.05).The ROC curve analysis showed that at the cut-off value of 2.295,β2M had a certain value in predicting moderate or severe WMHs,with an area under the ROC curve of 0.673(P<0.001).In the subgroup analysis,β2M was also identified as an independent risk factor for moderate or severe PWMHs(P=0.048),while no association was observed between β2M and the severity of DWMHs.Conclusion The se-rum level of β2M is associated with the severity of WMHs and PWMHs,but it is not associated with DWMHs.Further-more,β2M has a certain value in predicting moderate or severe WMHs.关键词
脑小血管病/脑白质高信号/β2微球蛋白/磁共振成像Key words
Cerebral small vessel disease/White matter hyperintensities/β2-Microglobulin/Magnetic reso-nance imaging分类
临床医学引用本文复制引用
王菲,刘婷婷,贺军,夏明武,王嵘峰..β2微球蛋白与脑白质高信号严重程度的相关性及其预测价值[J].中风与神经疾病杂志,2025,42(10):922-927,6.基金项目
合肥市卫生健康委员会应用医学研究项目(Hwk2022zd004) （Hwk2022zd004）
