中国耳鼻咽喉颅底外科杂志2025，Vol.31Issue(5)：18-22,5.DOI:10.11798/j.issn.1007-1520.202524565
新疆塔克拉玛干沙漠地区慢性化脓性中耳炎病原菌及药物敏感性分析
Analysis of pathogens and drug sensitivity of chronic suppurative otitis media in the Taklamakan Desert region of Xinjiang
摘要
Abstract
Objective To study the pathogens and the drug susceptibility in patients with chronic suppurative otitis media(CSOM)in the Taklamakan Desert region of Xinjiang,so as to provide a basis for the treatment of CSOM in this area.Methods Patients with CSOM treated in the Department of Otorhinolaryngology,General Hospital of the Third Division of Xinjiang Production and Construction Corps Affiliated to Guangdong Medical University from January 30,2024 to November 30,2024 were selected as the study subjects.The purulent secretions from the affected ears were collected for pathogen culture and drug sensitivity tests.The distribution of pathogens and drug sensitivity were statistically analyzed.Results A total of 176 patients were included in this study,and 121 cases were found to have pathogens,with a detection rate of 68.8％.A total of 122 strains of pathogens were identified,among which 73 strains(59.8％)were Gram-positive bacteria,with Staphylococcus aureus being the predominant,accounting for 66 strains(54.1％),including 54 strains(44.3％)of methicillin-sensitive Staphylococcus aureus(MSSA)and 12 strains(9.8％)of methicillin-resistant Staphylococcus aureus(MRSA).There were 32 strains(26.2％)of Gram-negative bacteria,Pseudomonas aeruginosa was the main type(17 strains,13.9％).Seventeen strains of fungi were detected(13.9％),with filamentous fungi being the predominant type(13 strains,10.7％).The drug sensitivity tests showed that MSSA had a relatively high resistance to penicillin,erythromycin and clindamycin,but demonstrated high sensitivity to drugs such as oxacillin,levofloxacin,linezolid,rifampicin,tigecycline and vancomycin.However,MRSA had a relatively high resistance to commonly used antibiotics such as oxacillin,erythromycin,clindamycin,and quinolones,but showed a high sensitivity to gentamicin,compound sulfamethoxazole,linezolid,rifampicin,tigecycline,and vancomycin.The resistance rate of Gram-negative bacteria to cefuroxime was high,while they were highly sensitive to ceftazidime,cefepime,gentamicin,imipenem and meropenemetc,etc.Conclusions The main pathogens causing CSOM in the Taklamakan Desert region of Xinjiang are Staphylococcus aureus,Pseudomonas aeruginosa,and Filamentous fungi,with relatively high proportions of MRSA and fungi.Early completion of bacteriological and mycological analysis is conducive to achieving more targeted treatment,shortening the course of the disease and improving the therapeutic effect.关键词
慢性化脓性中耳炎/病原菌/药物敏感性试验Key words
Chronic suppurative otitis media/Pathogen/Drug sensitivity test分类
临床医学引用本文复制引用
高士杰,王登锋,何玲玲,郭娟娟,张唯,巴育乾,祝小莉..新疆塔克拉玛干沙漠地区慢性化脓性中耳炎病原菌及药物敏感性分析[J].中国耳鼻咽喉颅底外科杂志,2025,31(5):18-22,5.基金项目
图木舒克市科技局资助项目(KY2024RC03). （KY2024RC03）
