中国耳鼻咽喉颅底外科杂志2025，Vol.31Issue(5)：86-89,4.DOI:10.11798/j.issn.1007-1520.202525069
颅底侵袭性曲霉菌感染的临床分析
Clinical analysis of invasive aspergillosis of the skull base
摘要
Abstract
Objective To investigate the clinical manifestations,diagnostic methods and treatment strategies of patients with invasive aspergillosis of the skull base in immunocompetent individuals.Methods Two cases of invasive aspergillosis of the skull base in immunocompetent patients were reported,detailing their clinical presentations,imaging features,surgical procedures,and antifungal treatments.Relevant literature was also reviewed.Results Both patients underwent endoscopic surgery to remove the lesions,with pathological confirmation of Aspergillus infection.Postoperative long-term antifungal therapy with voriconazole was administered,resulting in significant symptom improvement during follow-up.Conclusions Invasive aspergillosis of the skull base is rare in immunocompetent patients and challenging to diagnose.Typical appearances in image examinations are helpful for differential diagnosis.Endoscopic surgery combined with long-term antifungal therapy is an effective treatment strategy.Early diagnosis and aggressive treatment are crucial for improving prognosis.关键词
鼻内镜/颅底/侵袭性曲霉菌病/免疫功能Key words
Nasal endoscopy/Skull base/Invasive aspergillosis/Immunologic function分类
临床医学引用本文复制引用
李婕,贺楚峰,范若皓,高可雷..颅底侵袭性曲霉菌感染的临床分析[J].中国耳鼻咽喉颅底外科杂志,2025,31(5):86-89,4.基金项目
湖南省自然科学基金青年基金项目(2022JJ40780). （2022JJ40780）
