摘要
Abstract
Objective To observe the application effect of remimazolam combined with propofol anesthesia in patients undergoing laparoscopic radical resection of colorectal cancer(CRC).Methods A prospective study was conducted.A total of 62 patients scheduled for laparoscopic radical resection of CRC in our hospital from January 2022 to December 2024 were selected and randomly divided into an observation group and a con-trol group,with 31 cases in each group.Patients in the observation group were induced with remimazolam com-bined with propofol,while patients in the control group were induced with midazolam combined with propofol.The cognitive function and pain degree,anesthesia and awakening indicators,and hemodynamic indicators of the two groups of patients were compared,and the occurrence of anesthesia-related adverse reactions was statis-tically analyzed.Results On the 1st,3rd,and 5th days after surgery,the Mini-Mental State Examination(MMSE)scores of patients in the observation group were higher than those in the control group(P<0.05),and the Visual Analogue Scale(VAS)scores were lower than those in the control group(P<0.05).The anes-thesia onset time,recovery time of spontaneous breathing,and postoperative extubation time of patients in the observation group were shorter than those in the control group(P<0.05).Compared with before induction(T0),the heart rate(HR)of patients in the observation group slowed down at skin incision(T2),and the mean arterial pressure(MAP)decreased at intubation(T1)and T2(P<0.05).In the control group,the HR slowed down significantly at T2,and the MAP decreased significantly at T1,T2,and the end of surgery(T3)(P<0.05).There was no statistically significant difference in HR,MAP at different time points,and the total incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion Remimazolam combined with propofol has a significant anesthetic effect in laparoscopic radical resection of CRC.It is superior to midazolam combined with propofol anesthesia in shortening the anesthesia onset time,recovery time of spon-taneous breathing,and postoperative extubation time.At the same time,it can significantly improve the cogni-tive function of patients,relieve pain,and does not increase the incidence of adverse reactions.关键词
结直肠癌/腹腔镜/根治术/瑞马唑仑/丙泊酚Key words
Colorectal cancer/Laparoscopy/Radical resection/Remimazolam/Propofol
