中国康复理论与实践2025，Vol.31Issue(10)：1156-1163,8.DOI:10.3969/j.issn.1006-9771.2025.10.006
音乐干预对阿尔茨海默病患者激活模式区域差异的功能磁共振成像Meta分析
Regional differences in brain activation after music intervention for Alzheimer's disease:a meta-analysis of func-tional magnetic resonance imaging
摘要
Abstract
Objective To systematically investigate the impact of music intervention on neuroplasticity in patients with Alzheimer's disease(AD). Methods PubMed,EBSCOhost,Web of Science,Embase,CNKI,Wanfang data and VIP were searched for studies pub-lished up to February,2025.They were analysed using GingerALE 3.0.2 for meta-analysis. Results Five fMRI studies were included,involving 134 participants(99 with AD).A total of 49 activation coordinates were extracted.The main activation regions in the healthy group were concentrated in the left precuneus,the right inferior frontal gyrus and the right superior temporal gyrus,while the primary activated regions in AD group shifted to the right operculum and adjacent right insula,left superior frontal gyrus,right medial frontal gyrus,and left superior temporal gyrus,indicating that during music processing,neural activation patterns in AD patients shifted from higher-order associative cortices to subcortical structures,accompanied by compensatory changes in frontal lobe activation and a loss of activation in the parietal lobe,particularly in the precuneus. Conclusion Music intervention can activate the relatively preserved subcortical-limbic system in patients with AD and promote compensatory reorganization of the frontal lobes.关键词
阿尔茨海默病/音乐疗法/神经元可塑性/功能磁共振成像/Meta分析Key words
Alzheimer's disease/music therapy/neuroplasticity/functional magnetic resonance imaging/meta-analysis分类
临床医学引用本文复制引用
杨三峡,刘清栾,万嘉敏..音乐干预对阿尔茨海默病患者激活模式区域差异的功能磁共振成像Meta分析[J].中国康复理论与实践,2025,31(10):1156-1163,8.基金项目
湖北省教育厅哲学社会科学研究重点项目(No.23D039) Supported by Key Project of Philosophy and Social Sciences Research of Hubei Provincial Department of Education(No.23D039) （No.23D039）
